DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaTry and TMPRSS11A

DIOPT Version :9

Sequence 1:	NP_476771.1	Gene:	alphaTry / 48316	FlyBaseID:	FBgn0003863	Length:	256	Species:	Drosophila melanogaster
Sequence 2:	NP_872412.3	Gene:	TMPRSS11A / 339967	HGNCID:	27954	Length:	421	Species:	Homo sapiens

Alignment Length:	240	Identity:	82/240 - (34%)
Similarity:	119/240 - (49%)	Gaps:	15/240 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LLPQLDGRIVGGSATTISSFPWQISLQRSGSHSCGGSIYSANIIVTAAHCLQSVSASVLQVRAGS 87
            ::|....||..|.....:::|||.|||....|.||.::.|...:||||||.|..........:..
Human   182 VVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNPHQWTVSFG 246

  Fly    88 TYWSSGGVVAKVSSFKNHEGYNANTMVNDIAVIRLSSSLSFSSSIKAISL----ATYNPANGASA 148
            |..:...:...|..|..||.|.:.....||||:::||.::||..|:.|.|    |::.|  ..:.
Human   247 TKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPEASASFQP--NLTV 309

  Fly   149 AVSGWGTQSSGSSSIPSQLQYVNVNIVSQSQCASSTYGYGSQIRNTMICAA-ASG-KDACQGDSG 211
            .::|:|....|..| .:.|:...|.|:|...|..... ||:.|:..|.||. ..| .|||:||||
Human   310 HITGFGALYYGGES-QNDLREARVKIISDDVCKQPQV-YGNDIKPGMFCAGYMEGIYDACRGDSG 372

  Fly   212 GPLVSGGV-----LVGVVSWGYGCAYSNYPGVYADVAVLRSWVVS 251
            ||||:..:     |:|:||||..|...:.||||..|...|:|:.|
Human   373 GPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIAS 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTry	NP_476771.1	Tryp_SPc	30..249	CDD:214473	79/229 (34%)
TMPRSS11A	NP_872412.3	SEA	49..147	CDD:279699
		Tryp_SPc	189..415	CDD:214473	79/229 (34%)
		Tryp_SPc	190..418	CDD:238113	80/232 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910