DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaTry and F9

DIOPT Version :9

Sequence 1:	NP_476771.1	Gene:	alphaTry / 48316	FlyBaseID:	FBgn0003863	Length:	256	Species:	Drosophila melanogaster
Sequence 2:	NP_000124.1	Gene:	F9 / 2158	HGNCID:	3551	Length:	461	Species:	Homo sapiens

Alignment Length:	238	Identity:	81/238 - (34%)
Similarity:	111/238 - (46%)	Gaps:	27/238 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 RIVGGSATTISSFPWQISLQRSGSHSCGGSIYSANIIVTAAHCLQ-----SVSASVLQVRAGSTY 89
            |:|||.......||||:.|.......|||||.:...|||||||::     :|.|....:......
Human   226 RVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHT 290

  Fly    90 WSSGGVVAKVSSFKNHEGYNA--NTMVNDIAVIRLSSSLSFSSSIKAISLATYNPAN----GASA 148
            .....|:..:.    |..|||  |...:|||::.|...|..:|.:..|.:|.....|    ..|.
Human   291 EQKRNVIRIIP----HHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSG 351

  Fly   149 AVSGWG-TQSSGSSSIPSQLQYVNVNIVSQSQCASSTYGYGSQIRNTMICAA--ASGKDACQGDS 210
            .||||| ....|.|::  .|||:.|.:|.::.|..||   ...|.|.|.||.  ..|:|:|||||
Human   352 YVSGWGRVFHKGRSAL--VLQYLRVPLVDRATCLRST---KFTIYNNMFCAGFHEGGRDSCQGDS 411

  Fly   211 GGPLVS----GGVLVGVVSWGYGCAYSNYPGVYADVAVLRSWV 249
            |||.|:    ...|.|::|||..||.....|:|..|:...:|:
Human   412 GGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWI 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTry	NP_476771.1	Tryp_SPc	30..249	CDD:214473	80/236 (34%)
F9	NP_000124.1	GLA	28..92	CDD:214503
		EGF_CA	93..129	CDD:238011
		FXa_inhibition	134..170	CDD:317114
		Tryp_SPc	227..457	CDD:238113	80/237 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910