DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaTry and tmprss2.1

DIOPT Version :9

Sequence 1:	NP_476771.1	Gene:	alphaTry / 48316	FlyBaseID:	FBgn0003863	Length:	256	Species:	Drosophila melanogaster
Sequence 2:	XP_004912265.1	Gene:	tmprss2.1 / 101731874	XenbaseID:	XB-GENE-22065907	Length:	482	Species:	Xenopus tropicalis

Alignment Length:	255	Identity:	98/255 - (38%)
Similarity:	134/255 - (52%)	Gaps:	19/255 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VILLSAVVCALGGTVPEGLLPQLDGRIVGGSATTISSFPWQISLQRSGSHSCGGSIYSANIIVTA 69
            |:.|..:.|  |.:.     ..:..||||||..::..:|||:|||.:..|.|||||.:.|.|:||
Frog   229 VVTLRCIEC--GSST-----KNVGNRIVGGSQASLGDWPWQVSLQFNERHICGGSIITPNYILTA 286

  Fly    70 AHCLQSVSASVL--QVRAGSTYWSSGGVVAKVSSFKNHEGYNANTMVNDIAVIRLSSSLSFSSSI 132
            |||::.|.:|..  .|..||.|.|:||....|.|...|:.|:..|..||||::||.|.::.:|::
Frog   287 AHCVEGVYSSPYPWTVYVGSLYKSTGGTRYSVKSLIGHQNYDTKTKNNDIALMRLKSPITLTSTV 351

  Fly   133 KAISLATYNP--ANGASAAVSGWGTQSSGSSSIPSQLQYVNVNIVSQSQCASSTYGYGSQIRNTM 195
            :.:.|.....  .:|.|...||||....|.:| ...|....|.::....|..:.. |...:..||
Frog   352 QPVCLPNAGMLWTSGQSCWTSGWGATIEGGTS-SGVLNAAMVPLIDSDTCNRAVV-YNGAVTATM 414

  Fly   196 ICAA--ASGKDACQGDSGGPLV----SGGVLVGVVSWGYGCAYSNYPGVYADVAVLRSWV 249
            |||.  ..|.|:||||||||||    |...|||..|||.|||..|.||||.::..|..|:
Frog   415 ICAGYLRGGIDSCQGDSGGPLVTKTSSLWWLVGDTSWGTGCANMNKPGVYGNITELLPWI 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTry	NP_476771.1	Tryp_SPc	30..249	CDD:214473	93/228 (41%)
tmprss2.1	XP_004912265.1	LDLa	112..143	CDD:238060
		SRCR_2	148..241	CDD:373897	4/13 (31%)
		Tryp_SPc	248..474	CDD:238113	92/227 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X21
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000