DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaTry and tmprss2.12

DIOPT Version :9

Sequence 1:	NP_476771.1	Gene:	alphaTry / 48316	FlyBaseID:	FBgn0003863	Length:	256	Species:	Drosophila melanogaster
Sequence 2:	XP_031752400.1	Gene:	tmprss2.12 / 100497514	XenbaseID:	XB-GENE-22065925	Length:	497	Species:	Xenopus tropicalis

Alignment Length:	261	Identity:	101/261 - (38%)
Similarity:	146/261 - (55%)	Gaps:	28/261 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IVILLSAVVCALGGTVPEGLLPQLDGRIVGGSATTISSFPWQISLQRSGSHSCGGSIYSANIIVT 68
            :|:.|..:.|        ||....:.||||||:.:|..:|||::||...::.||||:.:||.|||
Frog   242 LVVSLKCIDC--------GLSTYGESRIVGGSSASIGDWPWQVNLQYDDTNLCGGSVIAANWIVT 298

  Fly    69 AAHCLQSVSAS-------VLQVRAGSTYWSSGGVVAKVSSFKNHEGYNANTMVNDIAVIRLSSSL 126
            ||||:|..::|       :.:::..|.|.||...|.::..   |..|::.|..||||:::|.:|:
Frog   299 AAHCVQGDTSSPSLWKAFIGKIKMPSYYDSSAYSVDRIIV---HPDYSSQTNSNDIALMKLKTSI 360

  Fly   127 SFSSSIKAISLATYNP--ANGASAAVSGWGTQSSGSSSIPSQLQYVNVNIVSQSQCASSTYGYGS 189
            :|||..:.:.|..|..  ..|....:||||| :|...||.|.|:|..|.::|.:.| :.|..|..
Frog   361 AFSSISRPVCLPNYGMQWEEGQPCYISGWGT-TSQKGSISSVLKYAMVPLISPTTC-NQTIMYNG 423

  Fly   190 QIRNTMICAA--ASGKDACQGDSGGPLV----SGGVLVGVVSWGYGCAYSNYPGVYADVAVLRSW 248
            .|.::||||.  ..|.|:||||||||||    |...|||..|||.|||....||||.::.|...|
Frog   424 AITSSMICAGYPKGGVDSCQGDSGGPLVTKTNSLWWLVGDTSWGDGCANVYRPGVYGNMTVFLQW 488

  Fly   249 V 249
            :
Frog   489 I 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTry	NP_476771.1	Tryp_SPc	30..249	CDD:214473	95/233 (41%)
tmprss2.12	XP_031752400.1	LDLa	127..155	CDD:238060
		SRCR_2	160..255	CDD:406055	5/20 (25%)
		Tryp_SPc	261..489	CDD:238113	94/232 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X21
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910