Protein Alignment Pkc53E and SCH9

DIOPT Version :10

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_012075.1
• Gene: SCH9 / 856612
• SGDID: S000001248
• Length: 824
• Species: Saccharomyces cerevisiae
• Alignment Length: 521
• Identity: 155/521 - (29%)
• Similarity: 267/521 - (51%)
• Gaps: 86/521 - (16%)

  Fly   185 NVKENLLTVQIKEGRNLIPMDP----NGLSDPYVKVKLIPDDKDQSKKKTRTIKACLN------- 238
            ::||:|....:...|:...:|.    :.::||             ||:.:.:.....|
Yeast   273 SIKEHLKKKPLYTHRSSSQLDQLNSCSSVTDP-------------SKRSSNSSSGSSNGPKNDSS 324

  Fly   239 -PVWNETLTYDLKPEDKDRRILIEVWDWDRTSRNDFMGALSFGISEIIKNPTNGWFKLLTQDEGE 302
             |:|:...|:|:.....:    :::..:|....:.|:|.:.  :..:|.|       |....:.:
Yeast   325 HPIWHHKTTFDVLGSHSE----LDISVYDAAHDHMFLGQVR--LYPMIHN-------LAHASQHQ 376

  Fly   303 YYNVPCADDEQDLLKLKQKPSQKKPMVMRSDTN-------THTSSKKDMIRATDFNFIKVLGKGS 360
            ::::                   ||.|:....:       |:..:||......||..:::||||:
Yeast   377 WHSL-------------------KPRVIDEVVSGDILIKWTYKQTKKRHYGPQDFEVLRLLGKGT 422

  Fly   361 FGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVL--ALGEKPPFLVQLHSCFQTMDR 423
            ||:|...::|.::.:||:|:|.|.||::.:::..|:.|:.:|  ...:..||:|.|...|||...
Yeast   423 FGQVYQVKKKDTQRIYAMKVLSKKVIVKKNEIAHTIGERNILVTTASKSSPFIVGLKFSFQTPTD 487

  Fly   424 LFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHV 488
            |:.|.:|::||:|.:.:|:.|:|.|..|.||.||:...|..||...|:|||||.:|:||||:|::
Yeast   488 LYLVTDYMSGGELFWHLQKEGRFSEDRAKFYIAELVLALEHLHDNDIVYRDLKPENILLDANGNI 552

  Fly   489 KIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQP-YGKSVDWWAYGVLLYEMLVGQPPFDGE 552
            .:.|||:.|.::  ...|.|||||.:|:|||::|.:. |.|.||:|:.|||::||..|..||..|
Yeast   553 ALCDFGLSKADL--KDRTNTFCGTTEYLAPELLLDETGYTKMVDFWSLGVLIFEMCCGWSPFFAE 615

  Fly   553 DEEELFAAITDHNVSYPKS-LSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFFRRIDWEKI 616
            :.::::..|....|.:|:. ||:|.:...||.|.:.|..|||....|.| :|.||||..||||.:
Yeast   616 NNQKMYQKIAFGKVKFPRDVLSQEGRSFVKGLLNRNPKHRLGAIDDGRE-LRAHPFFADIDWEAL 679

  Fly   617 ENREVQPPFKPKIKHRKDVSNFDKQFTSEKTD----------LTPTDKVFMMNLDQSEFVGFSYM 671
            :.:::.|||||.:....|.||||.:||:..|.          .||.....     |::|.||:::
Yeast   680 KQKKIPPPFKPHLVSETDTSNFDPEFTTASTSYMNKHQPMMTATPLSPAM-----QAKFAGFTFV 739

  Fly   672 N 672
            :
Yeast   740 D 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992	20/133 (15%)
		STKc_cPKC	353..672	CDD:270739	127/332 (38%)
SCH9	NP_012075.1	YPK1_N_like	181..407	CDD:212165	26/178 (15%)
		STKc_Sck1_like	418..738	CDD:270738	127/327 (39%)