Protein Alignment Pkc53E and CBK1

DIOPT Version :10

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_014238.3
• Gene: CBK1 / 855561
• SGDID: S000005105
• Length: 756
• Species: Saccharomyces cerevisiae
• Alignment Length: 570
• Identity: 145/570 - (25%)
• Similarity: 243/570 - (42%)
• Gaps: 160/570 - (28%)

  Fly   195 IKEGRNLIPMDPNGLSDPYVKVKLIPDDKDQ-SKKKTRTIKACLNPVWNETLTYDLKPEDKDRRI 258
            ::.|.|      ||....|:..:..||...: ::.|...:|..:...:..::.|.:  |..:||:
Yeast   253 VQSGFN------NGTISNYMYFERRPDLLTKGTQDKAAAVKLKIENFYQSSVKYAI--ERNERRV 309

  Fly   259 LIEV------WDWDRTSRNDFMGALSFGISEIIKNPTNGWFKLLTQDEGEYYNVPCADDEQDLLK 317
            .:|.      |..:|.||.         :|.:.|.                        |...|:
Yeast   310 ELETELTSHNWSEERKSRQ---------LSSLGKK------------------------ESQFLR 341

  Fly   318 LKQKPSQKKPMVMRSDTNTHTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILK 382
            |                      ::..:...||:.:||:|||:||:|.|.::|.:.::||:|.|.
Yeast   342 L----------------------RRTRLSLEDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLL 384

  Fly   383 KDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFK 447
            |..:.:.|.:.....|:.||| |...|::|.|:..||....|:.:||::.|||||..:.::..|.
Yeast   385 KSEMYKKDQLAHVKAERDVLA-GSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFT 448

  Fly   448 EPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMC---------------- 496
            |.|..||.||....:..:|..|.::||:|.||:|:|..||:|::|||:.
Yeast   449 EDVTRFYMAECILAIETIHKLGFIHRDIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLL 513

  Fly   497 -------------------------KENIVGDKTTKTF--------------------CGTPDYI 516
                                     ::.:|.|..:.|.                    .||||||
Yeast   514 QQDEATNGISKPGTYNANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYI 578

  Fly   517 APEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAIT--DHNVSYPKS--LSKEAK 577
            ||||.|||.||:..|||:.|.::||.|:|.|||..|..:|.:..|.  :..:.:|..  :|.||:
Yeast   579 APEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTLQFPDDIHISYEAE 643

  Fly   578 EACKGFLTKQPNKRLGCGSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQF 642
            :..:..|| ..::||| ...|.::::.|||||.:||..|  |:|:.|:.||:....|.    :.|
Yeast   644 DLIRRLLT-HADQRLG-RHGGADEIKSHPFFRGVDWNTI--RQVEAPYIPKLSSITDT----RFF 700

  Fly   643 TSEKTDLTPTDKVFMMNLDQSE----------------FVGFSYMNPEYV 676
            .:::.:..|..........|.|                |:|::|...:|:
Yeast   701 PTDELENVPDSPAMAQAAKQREQMTKQGGSAPVKEDLPFIGYTYSRFDYL 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992	20/118 (17%)
		STKc_cPKC	353..672	CDD:270739	119/399 (30%)
CBK1	NP_014238.3	MobB_CBK1	269..341	CDD:439268	16/106 (15%)
		STKc_NDR_like_fungal	350..748	CDD:270778	121/406 (30%)