Protein Alignment Pkc53E and YPK2

DIOPT Version :10

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_013822.1
• Gene: YPK2 / 855130
• SGDID: S000004710
• Length: 677
• Species: Saccharomyces cerevisiae
• Alignment Length: 468
• Identity: 161/468 - (34%)
• Similarity: 255/468 - (54%)
• Gaps: 65/468 - (13%)

  Fly   239 PVWNETLTYDLKPEDKDRRILIEVW-----------DWDRTSRNDFMGALSFGISEIIKN----- 287
            ||:|:..|:|:  ..|.|.:.|:|:           :|.:.     :|.....:.||:|.
Yeast   230 PVFNKISTFDV--TRKLRFLKIDVFARIPSLLLPSKNWQQE-----IGEQDEVLKEILKKINTNQ 287

  Fly   288 ---------PTNGWFKLLTQDEGEYYNVPCADDEQDLLKLK----QKPSQKKPMVMRSDTNTHTS 339
                     |.|  .|:.:..:...||......|:...||.    .|||:.||:.:
Yeast   288 DIHLDSFHLPLN--LKIDSAAQIRLYNHHWISLERGYGKLNITVDYKPSKNKPLSI--------- 341

  Fly   340 SKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLAL 404
                    .||:.:||:||||||||:...:|.::::||:|.|:|..|:...:|..|:.|:.|||.
Yeast   342 --------DDFDLLKVIGKGSFGKVMQVRKKDTQKIYALKALRKAYIVSKCEVTHTLAERTVLAR 398

  Fly   405 GEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKG 469
            .: .||:|.|...||:.::|:.|:.::|||:|.:.:|..|:|....:.||.||:...|..||...
Yeast   399 VD-CPFIVPLKFSFQSPEKLYLVLAFINGGELFYHLQHEGRFSLARSRFYIAELLCALDSLHKLD 462

  Fly   470 ILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWA 534
            ::|||||.:|:|||..||:.:.|||:||.|:..:..|.||||||:|:||||:|.|.|.|:||||.
Yeast   463 VIYRDLKPENILLDYQGHIALCDFGLCKLNMKDNDKTDTFCGTPEYLAPEILLGQGYTKTVDWWT 527

  Fly   535 YGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGE 599
            .|:|||||:.|.||:..|:...::..|....:.:|......||:...|.|::.|::|||.  :|.
Yeast   528 LGILLYEMMTGLPPYYDENVPVMYKKILQQPLLFPDGFDPAAKDLLIGLLSRDPSRRLGV--NGT 590

  Fly   600 EDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDKV---FMMNLD 661
            :::|.||||:.|.|:|:..:...||:||.:|...|.:|||::||.||    |.|.|   ::....
Yeast   591 DEIRNHPFFKDISWKKLLLKGYIPPYKPIVKSEIDTANFDQEFTKEK----PIDSVVDEYLSASI 651

  Fly   662 QSEFVGFSYMNPE 674
            |.:|.|::|:..|
Yeast   652 QKQFGGWTYIGDE 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992	19/92 (21%)
		STKc_cPKC	353..672	CDD:270739	131/321 (41%)
YPK2	NP_013822.1	YPK1_N_like	114..339	CDD:212165	26/117 (22%)
		Protein Kinases, catalytic domain	349..660	CDD:473864	129/317 (41%)