DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkc53E and Prkcq

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_001263650.1	Gene:	Prkcq / 85420	RGDID:	620968	Length:	707	Species:	Rattus norvegicus

Alignment Length:	665	Identity:	286/665 - (43%)
Similarity:	376/665 - (56%)	Gaps:	132/665 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 RKGALKKKNVFNVKDHCFIARFFKQPTFCSHCKDFICGYQSGYAWMGFGKQGFQCQVCSYVVHKR 95
            |:||:|:..|.:||.|.|.|.||.||||||.|.:|:        | |..|||:||:.|:..:||:
  Rat   145 RRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV--------W-GLNKQGYQCRQCNAAIHKK 200

  Fly    96 CHEYVTFICPGKDKGIDS------------DSPKTQHNFEPFTYAGPTFCDHCGSLLYGIYHQGL 148
            |.:.|...|.|  ..|:|            |.|   |.|:.:.|..||||:|||:||:|:..|||
  Rat   201 CIDKVIAKCTG--SAINSRETMFHKERFKIDMP---HRFKVYNYKSPTFCEHCGTLLWGLARQGL 260

  Fly   149 KCSACDMNVHARCKENVPSLCGCDHTERRGRIYLEINVK---ENLLTVQ-------IKEGRNLIP 203
            ||.||.||||.||:..|.:|||             ||.|   |.|..::       :::..::..
  Rat   261 KCDACGMNVHHRCQTKVANLCG-------------INQKLMAEALAMIESTQQARTLRDSEHIFR 312

  Fly   204 MDPNGLSDPYVKVKLIPDDKDQSKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRT 268
            ..|..:|.|                  |:||:...|....|      |..|:.:.:.    |:
  Rat   313 EGPIEISFP------------------RSIKSETRPPCVPT------PGKKEPQGIC----WE-- 347

  Fly   269 SRNDFMGALSFGISEIIKNPTNGWFKLLTQDEGEYYNVPCADDEQDLLKLKQKPSQKKPMVMRSD 333
                              :|.:|                 ||      |..|.|        ..:
  Rat   348 ------------------SPLDG-----------------AD------KTAQPP--------EPE 363

  Fly   334 TNTHTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIE 398
            .|...:|.:..::..||...|:|||||||||.|||.|.:::.:|||.|||||::.||||||||:|
  Rat   364 VNLQRASLQLKLKIDDFILHKMLGKGSFGKVFLAEFKRTKQFFAIKALKKDVVLMDDDVECTMVE 428

  Fly   399 KRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLF 463
            ||||:|..:.|||..:...|||.:.|||||||:||||||:.||...||....|.||||||..||.
  Rat   429 KRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQ 493

  Fly   464 FLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGK 528
            |||:|||:||||||||:|||.|||:|||||||||||::||..|.|||||||||||||:|.|.|..
  Rat   494 FLHSKGIVYRDLKLDNILLDRDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNH 558

  Fly   529 SVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLG 593
            |||||::||||||||:||.||.|:||||||.:|...|..||:.|.:|||:.......::|.||||
  Rat   559 SVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEREAKDLLVKLFVREPEKRLG 623

  Fly   594 CGSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDKVFMM 658
            .    ..|:|.||.||.|:||::|.:|:.|||:||:|...|.|||||:|.|||..|:..|:..:.
  Rat   624 V----RGDIRQHPLFREINWEELERKEIDPPFRPKVKSPYDCSNFDKEFLSEKPRLSFADRALIN 684

  Fly   659 NLDQSEFVGFSYMNP 673
            ::||:.|..||::||
  Rat   685 SMDQNMFSNFSFINP 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	28/65 (43%)
		C1_cPKC_rpt2	120..173	CDD:410386	30/52 (58%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	18/139 (13%)
		STKc_cPKC	353..672	CDD:270739	189/318 (59%)
Prkcq	NP_001263650.1	C1_1	160..212	CDD:278556	27/62 (44%)
		C1_1	232..284	CDD:278556	30/64 (47%)
		STKc_nPKC_theta	374..704	CDD:270770	193/330 (58%)
		S_TKc	380..634	CDD:214567	160/257 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910