DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc53E and YPK1

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_012796.1	Gene:	YPK1 / 853733	SGDID:	S000001609	Length:	680	Species:	Saccharomyces cerevisiae

Alignment Length:	517	Identity:	167/517 - (32%)
Similarity:	274/517 - (52%)	Gaps:	73/517 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 IYLEINVKENLLTVQ------IKEGRNLIPMDPNGLSDPYVKVKLIPDDKDQSKKKTRTIKACLN 238
            :|..|.....:.|::      .|.|.|.|.........||:|:.:.           ..|.:.|.
Yeast   210 LYFTIEFDNTVATIEAEYGTIAKPGFNKISTFDVTRKLPYLKIDVF-----------ARIPSILL 263

  Fly   239 PVWNETLTYDLKPEDKDRRILIEVWDWDRTSRNDFMGA--------LSFGISEIIKNPTNGWFKL 295
            |  ::|...::..:|:..:.:     :|:.:.|..:..        |||..:..|:...:.|
Yeast   264 P--SKTWQQEMGLQDEKLQTI-----FDKINSNQDIHLDSFHLPINLSFDSAASIRLYNHHW--- 318

  Fly   296 LTQDEG-EYYNVPCADDEQDLLKLKQKPSQKKPMVMRSDTNTHTSSKKDMIRATDFNFIKVLGKG 359
            :|.|.| ...|:          .:..|||:.||:.:                 .||:.:||:|||
Yeast   319 ITLDNGLGKINI----------SIDYKPSRNKPLSI-----------------DDFDLLKVIGKG 356

  Fly   360 SFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRL 424
            |||||:...:|.::::||:|.::|..|:...:|..|:.|:.|||..: .||:|.|...||:.::|
Yeast   357 SFGKVMQVRKKDTQKVYALKAIRKSYIVSKSEVTHTLAERTVLARVD-CPFIVPLKFSFQSPEKL 420

  Fly   425 FFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVK 489
            :||:.::|||:|.:.:|:.|:|....|.||.||:...|..||...::|||||.:|:|||..||:.
Yeast   421 YFVLAFINGGELFYHLQKEGRFDLSRARFYTAELLCALDNLHKLDVVYRDLKPENILLDYQGHIA 485

  Fly   490 IADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDE 554
            :.|||:||.|:..|..|.||||||:|:|||::|...|.|:||||..||||||||.|.||:..||.
Yeast   486 LCDFGLCKLNMKDDDKTDTFCGTPEYLAPELLLGLGYTKAVDWWTLGVLLYEMLTGLPPYYDEDV 550

  Fly   555 EELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFFRRIDWEKIENR 619
            .:::..|....:.:|....::||:...|.|::.|.:||  |.:|.:::|.||||.::.|:::..:
Yeast   551 PKMYKKILQEPLVFPDGFDRDAKDLLIGLLSRDPTRRL--GYNGADEIRNHPFFSQLSWKRLLMK 613

  Fly   620 EVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDKV---FMMNLDQSEFVGFSYMNPEYVFS 678
            ...||:||.:.:..|.||||::||.||    |.|.|   ::....|.:|.|::|:..|.:.|
Yeast   614 GYIPPYKPAVSNSMDTSNFDEEFTREK----PIDSVVDEYLSESVQKQFGGWTYVGNEQLGS 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992	26/141 (18%)
		STKc_cPKC	353..672	CDD:270739	132/321 (41%)
YPK1	NP_012796.1	YPK1_N_like	116..342	CDD:212165	30/162 (19%)
YPK1	NP_012796.1	PKc_like	352..663	CDD:419665	130/317 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910