Protein Alignment Pkc53E and PKC1

DIOPT Version :10

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_009445.2
• Gene: PKC1 / 852169
• SGDID: S000000201
• Length: 1151
• Species: Saccharomyces cerevisiae
• Alignment Length: 791
• Identity: 250/791 - (31%)
• Similarity: 363/791 - (45%)
• Gaps: 193/791 - (24%)

  Fly    31 RKGAL--KKKNVFNVKDHCFIARFFKQPTFCSHCKDFICGYQSGYAWMGFGKQGFQCQVCSYVVH 93
            |.||:  :|:.:|....|.|:.:.|.....|::|.||:     .|.       |||||.|.::.|
Yeast   398 RHGAIINRKEEIFEQHGHHFVQKSFYNIMCCAYCGDFL-----RYT-------GFQCQDCKFLCH 450

  Fly    94 KRCHEYVTFICPGK-DKGIDSDSPKTQ----HNFEPFTYAGPTFCDHCGSLLYGIYHQGLKCSAC 153
            |:|:..|...|..| ....|.|..|..    |.|.|.:..|..:|.|||.:|....|:..|||.|
Yeast   451 KKCYTNVVTKCIAKTSTDTDPDEAKLNHRIPHRFLPTSNRGTKWCCHCGYILPWGRHKVRKCSEC 515

  Fly   154 DMNVHARCKENVPSLCGCDHTERRGRIYLEI-----NVKENLLTVQIKE---------GRNLIPM 204
            .:..||:|...||..||.. .|...:|...|     |.::...||...:         |.:|.|.
Yeast   516 GIMCHAQCAHLVPDFCGMS-MEMANKILKTIQDTKRNQEKKKRTVPSAQLGSSIGTANGSDLSPS 579

  Fly   205 -----------------------------DPNGLSDPYV------------KVKLIPDDKD---- 224
                                         .|....||.:            |:....|:.:
Yeast   580 KLAERANAPLPPQPRKHDKTPSPQKVGRDSPTKQHDPIIDKRISLQTHGREKLNKFIDENEAYLN 644

  Fly   225 -----------QSKKKTRTIKACLNPVWNE--------TLTYDLKPEDKD--RRILIEVW----- 263
                       .|.:||      |:|..|.        ::.:....|.||  .|..:|:|
Yeast   645 FTEGAQQTAEFSSPEKT------LDPTSNRRSLGLTDLSIEHSQTWESKDDLMRDELELWKAQRE 703

  Fly   264 ------------------------------DWDRTSRNDFMGALSFGISEIIKNPTNGWFKLLTQ 298
                                          ||:  ::|||..|                  .||.
Yeast   704 EMELEIKQDSGEIQEDLEVDHIDLETKQKLDWE--NKNDFREA------------------DLTI 748

  Fly   299 DEGEYYNVPCADDEQDLLKLKQKPSQKKPM---VMRSDTNTHTS--------------------- 339
            |  ..:..|..|...:..:::|..:.|:.:   |..:.|:||.|
Yeast   749 D--STHTNPFRDMNSETFQIEQDHASKEVLQETVSLAPTSTHASRTTDQQSPQKSQTSTSAKHKK 811

  Fly   340 --SKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRV- 401
              :|:..:...:|..:||||||:||||:|::.|.::.|.|||:||||.|||:.|:|....||:|
Yeast   812 RAAKRRKVSLDNFVLLKVLGKGNFGKVILSKSKNTDRLCAIKVLKKDNIIQNHDIESARAEKKVF 876

  Fly   402 -LALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFL 465
             ||...|.|||..|:..|||.:|::|.||::.|||||:.:|. .:.....|.|||||:...|.:.
Yeast   877 LLATKTKHPFLTNLYCSFQTENRIYFAMEFIGGGDLMWHVQN-QRLSVRRAKFYAAEVLLALKYF 940

  Fly   466 HTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSV 530
            |..|::||||||:|:||..:||:||||:|:||:.:.....|.||||||:::||||:..|.|.|:|
Yeast   941 HDNGVIYRDLKLENILLTPEGHIKIADYGLCKDEMWYGNRTSTFCGTPEFMAPEILKEQEYTKAV 1005

  Fly   531 DWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCG 595
            ||||:|||||:||:.|.||.|:||:|:|.||......||..::.|..:..:|.|||.|.||||.|
Yeast  1006 DWWAFGVLLYQMLLCQSPFSGDDEDEVFNAILTDEPLYPIDMAGEIVQIFQGLLTKDPEKRLGAG 1070

  Fly   596 SSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDKVFMMNL 660
            ....::|...||||.|:::.|.|..|:||:.|:||..:|.|.|:::|||....|||...| :...
Yeast  1071 PRDADEVMEEPFFRNINFDDILNLRVKPPYIPEIKSPEDTSYFEQEFTSAPPTLTPLPSV-LTTS 1134

  Fly   661 DQSEFVGFSYM 671
            .|.||.|||:|
Yeast  1135 QQEEFRGFSFM 1145

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	20/66 (30%)
		C1_cPKC_rpt2	120..173	CDD:410386	21/52 (40%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	34/244 (14%)
		STKc_cPKC	353..672	CDD:270739	155/321 (48%)
PKC1	NP_009445.2	HR1_PKC-like_1_fungi	1..72	CDD:212011
		HR1_PKC-like_2_fungi	110..181	CDD:212010
		C2_fungal_Pkc1p	211..319	CDD:176071
		C1_ScPKC1-like_rpt1	413..464	CDD:410372	19/62 (31%)
		C1_ScPKC1-like_rpt2	478..536	CDD:410373	21/58 (36%)
		STKc_PKC	828..1145	CDD:270722	154/318 (48%)