DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pkc53E and DOC2B

DIOPT Version :9

Sequence 1:NP_725626.1 Gene:Pkc53E / 48311 FlyBaseID:FBgn0003091 Length:679 Species:Drosophila melanogaster
Sequence 2:NP_003576.2 Gene:DOC2B / 8447 HGNCID:2986 Length:412 Species:Homo sapiens


Alignment Length:236 Identity:76/236 - (32%)
Similarity:102/236 - (43%) Gaps:59/236 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   103 ICPGKDKGIDSDSPKTQHNF------EPFTYAGPTFCDHCGSLLYGIYHQGLKCSACDMNVHARC 161
            :.||..|. :....||..|.      |..||.|.|..|        :..:.|:.|.||.:   :.
Human   170 LLPGASKA-NKLRTKTLRNTLNPTWNETLTYYGITDED--------MIRKTLRISVCDED---KF 222

  Fly   162 KEN-------VP------------SLC-----GCDHT-----ERRGRIYLEI---NVKENLLTVQ 194
            :.|       ||            |:|     ..|.|     |.||||.:.:   :.|:.|| |.
Human   223 RHNEFIGETRVPLKKLKPNHTKTFSICL
EKQLPVDKTEDKSLEERGRILISLKYSSQKQGLL-VG 286

  Fly   195 IKEGRNLIPMDPNGLSDPYVKVKLIPDDKDQSKKKTRTIKACLNPVWNETLTYDLKPEDKDRRIL 259
            |....:|..||.||.||||||..|.||...:||.||...|..|||.:||...|::|..|..::.|
Human   287 IVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSL 351

  Fly   260 -IEVWDWDRTSRNDFMGALSFGI---SEIIKNPTNGWFKLL 296
             :.|||:|....|||:|.:..||   .|.:|:    ||..|
Human   352 EVTVWDYDIGKSNDFIGGVVLGIHAKGERLKH----WFDCL 388

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pkc53ENP_725626.1 C1_cPKC_rpt1 44..110 CDD:410383 2/6 (33%)
C1_cPKC_rpt2 120..173 CDD:410386 16/82 (20%)
C2_PKC_alpha_gamma 177..307 CDD:175992 52/127 (41%)
STKc_cPKC 353..672 CDD:270739
DOC2BNP_003576.2 Mediates interaction with DYNLT1. /evidence=ECO:0000269|PubMed:9804756 1..90
Negatively regulates targeting to plasma membrane. /evidence=ECO:0000250 1..36
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 38..123
C2A_Rabphilin_Doc2 127..250 CDD:176000 20/91 (22%)
Mediates interaction with STXBP3. /evidence=ECO:0000250 257..375 49/118 (42%)
C2B_Rabphilin_Doc2 269..401 CDD:176030 50/125 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.