DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc53E and Doc2b

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_112404.1	Gene:	Doc2b / 81820	RGDID:	620519	Length:	412	Species:	Rattus norvegicus

Alignment Length:	384	Identity:	98/384 - (25%)
Similarity:	151/384 - (39%)	Gaps:	75/384 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 ICPGKDKGID--------------------SDSPKTQHNFEPFTYAGPTF-------CDHCGSLL 140
            :|||..:.|.                    :.:|.......|...|||..       .|.....|
  Rat    22 VCPGPIRPIKQISDYFPRFPRGLPPTAAPRASAPPDAPARSPAATAGPRSPSDGARDDDEDVDQL 86

  Fly   141 YGIY--HQGLKCSACDMNVHARCKENVPSLCGCDHTERRGRIYLEINV----KENLLTVQIKEGR 199
            :|.|  ..|.......:...|:..|:.|...|.:..:......|:.::    :.|.|...|.:.:
  Rat    87 FGAYGASPGPSPGPSPVRPPAKPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTISKAK 151

  Fly   200 NLIPMDPNGLSDPYVKVKLIPDDKDQSKKKTRTIKACLNPVWNETLT-YDLKPEDKDRRIL-IEV 262
            .|.|||.|||:|||||:.|:|.....:|.:|:|::..|||.|||||| |.:..||..|:.| |.|
  Rat   152 GLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPSWNETLTYYGITDEDMIRKTLRISV 216

  Fly   263 WDWDRTSRNDFMGALSFGISEIIKNPTNGWF----KLLTQDEGEYYNVPCADDEQD--LLKLKQK 321
            .|.|:...|:|:|.....:.::..|.|..:.    |.|..|:.|..::    :|:.  |:.||..
  Rat   217 CDEDKFRHNEFIGETRVPLKKLKPNHTKTFSICLEKQLPVDKAEDKSL----EERGRILISLKYS 277

  Fly   322 PSQKKPMVM---------------RSDTNTHTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKG 371
             |||:.:::               .||....|..|.|:.:       |...|.:..|..|.....
  Rat   278 -SQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLKPDVDK-------KSKHKTAVKKKTLNPEFN 334

  Fly   372 SEELYAIK---ILKK--DVIIQDDDV--ECTMIEKRVLALGEKPPFLVQLHSCFQTMDR 423
            .|..|.||   :.||  :|.:.|.|:  ....|...||.:..|...|.....|.:..|:
  Rat   335 EEFCYEIKHGDLAKKTLEVTVWDYDIGKSNDFIGGVVLGINAKGERLKHWFDCLKNKDK 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	3/6 (50%)
		C1_cPKC_rpt2	120..173	CDD:410386	13/61 (21%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	48/139 (35%)
		STKc_cPKC	353..672	CDD:270739	20/78 (26%)
Doc2b	NP_112404.1	Mediates interaction with DYNLT1. /evidence=ECO:0000250	1..90		12/67 (18%)
		Negatively regulates targeting to plasma membrane. /evidence=ECO:0000250	1..36		4/13 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..123		14/84 (17%)
		C2A_Rabphilin_Doc2	127..250	CDD:176000	44/122 (36%)
		Mediates interaction with STXBP3. /evidence=ECO:0000250	257..375		30/129 (23%)
		C2B_Rabphilin_Doc2	269..401	CDD:176030	31/133 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910