Protein Alignment Pkc53E and Prkch

DIOPT Version :10

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_112347.1
• Gene: Prkch / 81749
• RGDID: 621888
• Length: 683
• Species: Rattus norvegicus
• Alignment Length: 656
• Identity: 282/656 - (42%)
• Similarity: 365/656 - (55%)
• Gaps: 139/656 - (21%)

  Fly    28 SRLRKGALKKKNVFNVKDHCFIARFFKQPTFCSHCKDFICGYQSGYAWMGFGKQGFQCQVCSYVV 92
            :|.|:.|:::: |..|..|.|:|.:.:|||:||||::||        |..|||||:|||||:.||
  Rat   155 TRKRQRAMRRR-VHQVNGHKFMATYLRQPTYCSHCREFI--------WGVFGKQGYQCQVCTCVV 210

  Fly    93 HKRCHEYVTFICPGKD--KGIDSDSPKTQ------HNFEPFTYAGPTFCDHCGSLLYGIYHQGLK 149
            |||||..:...|..::  ..:|:...:.:      |.|....|..|||||||||||:||..|||:
  Rat   211 HKRCHHLIVTACTCQNNINKVDAKIAEQRFGINIPHKFNVHNYKVPTFCDHCGSLLWGIMRQGLQ 275

  Fly   150 CSACDMNVHARCKENVPSLCGCDHTERRGRIYLEINVKENLLTVQIKEGRNLIPMDPNGLSDPYV 214
            |..|.||||.||:.||...||             :|..|...|:   .|..|.|
  Rat   276 CKICKMNVHIRCQANVAPNCG-------------VNAVELAKTL---AGMGLQP----------- 313

  Fly   215 KVKLIPDDKDQSKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRTSRNDFMGALSF 279
                                                                        |.:|
  Rat   314 ------------------------------------------------------------GNIS- 317

  Fly   280 GISEIIKNPTNGWFKLLTQDEGEYYNVPCADDEQDLLKLKQKPSQKKPMVMRSDTNTHTSSKKDM 344
                    ||:   ||::               :..|:.:.|...|:    .:....::||:
  Rat   318 --------PTS---KLIS---------------RSTLRRQGKEGSKE----GNGIGVNSSSR--- 349

  Fly   345 IRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPP 409
            ....:|.||:||||||||||:||..|.:.||||:|:||||||:|||||||||.|||:|:|....|
  Rat   350 FGIDNFEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHP 414

  Fly   410 FLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRD 474
            ||.||..||||.||||||||:||||||||.||:..:|.|..|.||||||.:.|.|||.|||:|||
  Rat   415 FLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHEKGIIYRD 479

  Fly   475 LKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLL 539
            |||||||||.:||.|:||||||||.|....||.|||||||||||||:....||.:|||||.||||
  Rat   480 LKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLL 544

  Fly   540 YEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLG-CGSSGEEDVR 603
            ||||.|..||:.|:|::||.||.:..|.||..|.::|....|.|:||.|..||| ....||.::.
  Rat   545 YEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHEIL 609

  Fly   604 LHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDKVFMMNLDQSEFVGF 668
            .||||:.|||.::.:|:::|||:|:||.|:||||||..|..|:..|||.|:..:..::|.||..|
  Rat   610 RHPFFKEIDWVQLNHRQLEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNF 674

  Fly   669 SYMNPE 674
            ||::||
  Rat   675 SYVSPE 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	31/67 (46%)
		C1_cPKC_rpt2	120..173	CDD:410386	31/52 (60%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	12/129 (9%)
		STKc_cPKC	353..672	CDD:270739	193/319 (61%)
Prkch	NP_112347.1	C2_PKC_epsilon	8..140	CDD:175981
		C1_nPKC_epsilon-like_rpt1	166..226	CDD:410385	33/67 (49%)
		C1_nPKC_epsilon-like_rpt2	244..298	CDD:410388	31/66 (47%)
		STKc_nPKC_eta	359..681	CDD:270742	194/322 (60%)