DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkc53E and SGK1

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_001137148.1	Gene:	SGK1 / 6446	HGNCID:	10810	Length:	526	Species:	Homo sapiens

Alignment Length:	525	Identity:	174/525 - (33%)
Similarity:	268/525 - (51%)	Gaps:	94/525 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 YVKVKLIPDDKDQSKK------------------KTRTIKACLN---------PVWNETLTYD-- 248
            ::|..::..||.||..                  ::...:.||.         |..||:.:::
Human    27 WIKSPMVSVDKHQSPSLKYTGSSMVHIPPGEPDFESSLCQTCLGEHAFQRGVLPQENESCSWETQ 91

  Fly   249 ---------------LKPEDKDRRILIEVWDWDRTSRNDFMGALSFGISEIIKNPTNGWFKLLTQ 298
                           .||:.:      ..|..|..:   ||.....|:::.|:...|.
Human    92 SGCEVREPCNHANILTKPDPR------TFWTNDDPA---FMKQRRMGLNDFIQKIANN------- 140

  Fly   299 DEGEYYNVPCADDE-QDLLKLKQ-------------KPSQKKPMVMRSDTNTHTSSKKDMIRATD 349
                  :..|...| |.:||:.|             .||..:.:.:...:|.|.       :.:|
Human   141 ------SYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHA-------KPSD 192

  Fly   350 FNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQL 414
            |:|:||:|||||||||||..|..|..||:|:|:|..|::..:.:..|.|:.||....|.||||.|
Human   193 FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGL 257

  Fly   415 HSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDN 479
            |..|||.|:|:||::|:|||:|.:.:|:...|.||.|.|||||||:.|.:||:..|:|||||.:|
Human   258 HFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPEN 322

  Fly   480 VLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLV 544
            :|||:.||:.:.|||:|||||..:.||.||||||:|:|||::..|||.::||||..|.:|||||.
Human   323 ILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLY 387

  Fly   545 GQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFFR 609
            |.|||...:..|::..|.:..:....:::..|:...:|.|.|...||||......| ::.|.||.
Human   388 GLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFME-IKSHVFFS 451

  Fly   610 RIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSE----KTDLTPTDKVFMMNLDQS--EFVGF 668
            .|:|:.:.|:::.|||.|.:....|:.:||.:||.|    ....:|...:...::.::  .|:||
Human   452 LINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGF 516

  Fly   669 SYMNP 673
            ||..|
Human   517 SYAPP 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992	19/137 (14%)
		STKc_cPKC	353..672	CDD:270739	141/324 (44%)
SGK1	NP_001137148.1	S_TKc	193..450	CDD:214567	122/257 (47%)
SGK1	NP_001137148.1	STKc_SGK	197..519	CDD:270727	140/322 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920