DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc53E and sgk3

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_001103937.1	Gene:	sgk3 / 564523	ZFINID:	ZDB-GENE-070424-62	Length:	486	Species:	Danio rerio

Alignment Length:	402	Identity:	163/402 - (40%)
Similarity:	232/402 - (57%)	Gaps:	30/402 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 SEIIKNPTNGWFKLLTQDEGEYYNVPCADDEQDLLKLKQKPSQKKPMVMRSDTNTHTSSKKDMIR 346
            |::..:|....|  |..|:.:.:: ..::||.|     :..|..:.:.:....|.|.       :
Zfish    99 SQLCSHPDVKVF--LQMDKAKNFS-DGSEDEDD-----KSNSTSRNINLGPSANPHA-------K 148

  Fly   347 ATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFL 411
            .|||:|:||:|||||||||||:||...:.||||:|:|.||:...:.:..|.|:.||....|.|||
Zfish   149 PTDFDFLKVIGKGSFGKVLLAKRKRDGKCYAIKVLQKKVILNRREQKHIMAERNVLLKNVKHPFL 213

  Fly   412 VQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLK 476
            |.||..|||.|:|:||:::||||:|.|.:|:...|.||.|.||.||:|:.|.:||:..|:|||||
Zfish   214 VGLHYSFQTTDKLYFVLDFVNGGELFFHLQKERTFPEPRAKFYIAEMASALGYLHSLNIVYRDLK 278

  Fly   477 LDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYE 541
            .:|:|||:.||:.:.|||:|||.|....||.||||||:|:|||::..|||..:||||..|.:|||
Zfish   279 PENILLDSQGHIVLTDFGLCKEGISQADTTTTFCGTPEYLAPEVLRKQPYDNTVDWWCLGSVLYE 343

  Fly   542 MLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHP 606
            ||.|.|||...|..|::..|....:......|..|....:..|.|...:|||......| |:.|.
Zfish   344 MLYGLPPFYSRDTHEMYDNILHKELVMRPGASTAAWSILQTLLEKDHTRRLGYRDDFNE-VKEHE 407

  Fly   607 FFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDKVF----------MMNLD 661
            ||..|:|..:|.:::.|||.|.::.:.|:||||.:||.|   ..|....|          :|..|
Zfish   408 FFSSINWYDLEQKKLPPPFNPSVESQYDISNFDPEFTEE---TVPNSVCFSSGPSIVNASVMEAD 469

  Fly   662 QSEFVGFSYMNP 673
            .: |:||||..|
Zfish   470 DA-FLGFSYAPP 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992	5/24 (21%)
		STKc_cPKC	353..672	CDD:270739	147/328 (45%)
sgk3	NP_001103937.1	PX_CISK	6..114	CDD:132780	4/16 (25%)
		S_TKc	152..409	CDD:214567	123/257 (48%)
		STKc_SGK3	155..480	CDD:270755	147/329 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920