DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc53E and pkn1a

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	XP_005160107.3	Gene:	pkn1a / 560840	ZFINID:	ZDB-GENE-061207-17	Length:	967	Species:	Danio rerio

Alignment Length:	369	Identity:	178/369 - (48%)
Similarity:	238/369 - (64%)	Gaps:	13/369 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 DLLKLKQKPSQKKPMV---MRSDTNTHTSS---KKDMIRATDFNFIKVLGKGSFGKVLLAERKGS 372
            |:...:::|| .:|:.   :.:...||:.|   ||..:...||..|.|||:|.||||||||.|.|
Zfish   599 DISTPERQPS-TEPLSAPDVTTPIRTHSLSSKQKKTSLSLQDFRLIAVLGRGHFGKVLLAEYKKS 662

  Fly   373 EELYAIKILKKDVIIQDDDVECTMIEKRVLAL--GEKPPFLVQLHSCFQTMDRLFFVMEYVNGGD 435
            ..:||||.|||..|:..|:||..|.|||:...  |.:.||||.|.:||||.:.:.|||||..|||
Zfish   663 GSMYAIKALKKGDIVARDEVESLMCEKRIFEAVNGAQHPFLVNLFACFQTPEHVCFVMEYTAGGD 727

  Fly   436 LMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENI 500
            ||..|.. ..|.||.||||:|.:..||.|||...|:||||||||:|||.:|:|||||||:|||.:
Zfish   728 LMMHIHA-DVFTEPRAVFYSACVVLGLQFLHDNKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGM 791

  Fly   501 -VGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDH 564
             .||:|: ||||||:::|||::....|.::||||..|||:||||||:.||.|:||||:|.:|.:.
Zfish   792 GFGDRTS-TFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVND 855

  Fly   565 NVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKI 629
            .|.||:.||.||....:..|.:.|.:|||......|||:..||||.:|||.:..|::.|||.|.|
Zfish   856 EVRYPRFLSAEAIGIMRRLLRRNPERRLGSSEKDAEDVKKQPFFRNMDWEALLLRKLPPPFIPSI 920

  Fly   630 KHRKDVSNFDKQFTSEKTDLT-PTDKVFMMNLDQSEFVGFSYMN 672
            ..::||||||::||:|...|| |.:...:...||..|..|.|::
Zfish   921 GGKEDVSNFDEEFTTEAPTLTPPREPRVLSRKDQDSFRDFDYVS 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992
		STKc_cPKC	353..672	CDD:270739	167/322 (52%)
pkn1a	XP_005160107.3	HR1_PKN_1	71..136	CDD:212012
		HR1_PKN1_2	156..233	CDD:212020
		HR1	237..310	CDD:320753
		C2	421..508	CDD:326325
		STKc_PKN	640..965	CDD:270741	168/327 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583319
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.870