Protein Alignment Pkc53E and PRKG1

DIOPT Version :10

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_006249.1
• Gene: PRKG1 / 5592
• HGNCID: 9414
• Length: 686
• Species: Homo sapiens
• Alignment Length: 704
• Identity: 185/704 - (26%)
• Similarity: 300/704 - (42%)
• Gaps: 141/704 - (20%)

  Fly    11 PQQQGAEGEAVGENKMKSRLRKGALK-KKNVFNVKD--HCFIARFFKQPTFCSHCKDFICGYQSG 72
            |..|.|:.::....:.:.|.::.|:. :...|:::|  |..:..:.|.|    ..||.|   :..
Human    55 PATQQAQKQSASTLQGEPRTKRQAISAEPTAFDIQDLSHVTLPFYPKSP----QSKDLI---KEA 112

  Fly    73 YAWMGFGKQGFQCQV-----CSYVVHKRCHEYVTFICPGKDKGIDSDSPKTQHNFEPFTYAGPTF 132
            .....|.|.....|:     |.|.|     ||      |||..|..:.
Human   113 ILDNDFMKNLELSQIQEIVDCMYPV-----EY------GKDSCIIKEG----------------- 149

  Fly   133 CDHCGSLLYGIYHQGLKCSACDMNVHARCKENVPSLCGCDHTERRGRIYLEINVKENLL-TVQIK 196
              ..|||:|.:....::.:          ||.| .||    |...|:::.|:.:..|.. |..:|
Human   150 --DVGSLVYVMEDGKVEVT----------KEGV-KLC----TMGPGKVFGELAILYNCTRTATVK 197

  Fly   197 EGRNLIPMDPNGLSDPYVKVKLIPDDK---DQSKKKTRTIKACLNPVWNETL----TYDLKPEDK 254
                           ..|.|||...|:   .....:|..||   :..:.|.|    |:...||:
Human   198 ---------------TLVNVKLWAIDRQCFQTIMMRTGLIK---HTEYMEFLKSVPTFQSLPEE- 243

  Fly   255 DRRILIEVWD-WDRT------------SRNDFMGALSFGISEIIK--NPTNGWFKLLTQDEGEYY 304
               ||.::.| .:.|            :|.|....:|.|...:.:  :|:.....|.|..:|:::
Human   244 ---ILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWF 305

  Fly   305 N-------------------VPCADDEQDLLK--------LKQKPSQKKPMVMRSDTNTHTSSKK 342
            .                   |.|...::|..|        :..|..:......:.:......:.
Human   306 GEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFAN- 369

  Fly   343 DMIRATDFNFIKVLGKGSFGKVLLAERKGSE-ELYAIKILKKDVIIQDDDVECTMIEKRVLALGE 406
              ::.:|||.|..||.|.||:|.|.:.|..| :.:|:|||||..|:.....|....||:::. |.
Human   370 --LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQ-GA 431

  Fly   407 KPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGIL 471
            ...|:|:|:..|:....|:.:||...||:|...::..|.|::....||.|.:.....:||:|||:
Human   432 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGII 496

  Fly   472 YRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYG 536
            |||||.:|::||..|:.|:.|||..|:...|.||. ||||||:|:||||||.:.:..|.|:|:.|
Human   497 YRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTW-TFCGTPEYVAPEIILNKGHDISADYWSLG 560

  Fly   537 VLLYEMLVGQPPFDGEDEEELFAAITD--HNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGE 599
            :|:||:|.|.|||.|.|..:.:..|..  ..:.:||.::|.|....|......|::|||...:|.
Human   561 ILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGV 625

  Fly   600 EDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTD 653
            :|::.|.:|...:||.:....:.||..|.:....|.|||| .|..:..:..|.|
Human   626 KDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFD-SFPEDNDEPPPDD 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	18/72 (25%)
		C1_cPKC_rpt2	120..173	CDD:410386	9/52 (17%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	30/171 (18%)
		STKc_cPKC	353..672	CDD:270739	112/304 (37%)
PRKG1	NP_006249.1	DD_cGKI-beta	4..55	CDD:213375	185/704 (26%)
		CAP_ED	118..227	CDD:237999	35/171 (20%)
		CAP_ED	237..341	CDD:237999	18/107 (17%)
		STKc_cGK	381..641	CDD:270724	99/261 (38%)
		S_TK_X	636..>679	CDD:214529	13/44 (30%)