Protein Alignment Pkc53E and PRKCZ

DIOPT Version :10

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: XP_016857278.1
• Gene: PRKCZ / 5590
• HGNCID: 9412
• Length: 603
• Species: Homo sapiens
• Alignment Length: 702
• Identity: 217/702 - (30%)
• Similarity: 307/702 - (43%)
• Gaps: 215/702 - (30%)

  Fly    11 PQQQGAEGEAVGENKMKSRLRKGALKKKNVFNVKDH----CFIARFFKQPTF---CSHCKDFICG 68
            |.:.|.:.|..|     .|:|           :|.|    .||.......||   |...:| :|.
Human     2 PSRTGPKMEGSG-----GRVR-----------LKAHYGGDIFITSVDAATTFEELCEEVRD-MCR 49

  Fly    69 YQSGY----AWMGFGKQGFQCQVCS-------YVVHKRCHEYVTFI-------------CPGKDK 109
            ....:    .|:  ..:|..|.|.|       :.:.::|.:....|             |||:||
Human    50 LHQQHPLTLKWV--DSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDK 112

  Fly   110 GIDSDSPK--------TQHNFEPFTYAGPTFCDHCGSLLYGIYHQGLKCSACDMNVHARCKENVP 166
            .|.....:        ..|.|:...:....:|..|...::|:..||.:|..|.:.||.||...||
Human   113 SIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVP 177

  Fly   167 SLCGCDHTERRGRIYLEINVKENLLTVQIKEGRNLIPMDPNGLSDPYVKVKLIPDDKDQSKKKTR 231
            ..|         |.:::                :::|.     .:|.|      |||::..
Human   178 LTC---------RKHMD----------------SVMPS-----QEPPV------DDKNEDA---- 202

  Fly   232 TIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRTSRNDFMGALSFGISEIIKNPTNGWFKLL 296
                            ||..|:.|                        ||:.|..:..:...|
Human   203 ----------------DLPSEETD------------------------GIAYISSSRKHDSIK-- 225

  Fly   297 TQDEGEYYNVPCADDEQDLLKLKQKPSQKKPMVMRSDTNTHTSSKKDMIRAT------DFNFIKV 355
                         ||.:||          ||::          ...|.|:.:      ||:.|:|
Human   226 -------------DDSEDL----------KPVI----------DGMDGIKISQGLGLQDFDLIRV 257

  Fly   356 LGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQT 420
            :|:||:.||||...|.::::||:|::||:::..|:|::....||.|.......||||.|||||||
Human   258 IGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQT 322

  Fly   421 MD--------RLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKL 477
            ..        |||.|:||||||||||.:|:..|..|..|.||||||...|.|||.:||:||||||
Human   323 TSRLRRLSPCRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKL 387

  Fly   478 DNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEM 542
            ||||||||||:|:.|:|||||.:....||.||||||:||||||:..:.||.||||||.|||::||
Human   388 DNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEM 452

  Fly   543 LVGQPPF-------DGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGC-GSSGE 599
            :.|:.||       |...|:.||..|.:..:..|:.||.:|....||||.|.|.:|||| ..:|.
Human   453 MAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGF 517

  Fly   600 EDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTP 651
            .|::.|.|||.|||:              :.||:      .:.|..:|..||
Human   518 SDIKSHAFFRSIDWD--------------LMHRQ------LRCTDARTTWTP 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	20/96 (21%)
		C1_cPKC_rpt2	120..173	CDD:410386	16/52 (31%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	15/129 (12%)
		STKc_cPKC	353..672	CDD:270739	148/315 (47%)
PRKCZ	XP_016857278.1	PB1_aPKC	16..98	CDD:99725	17/95 (18%)
		C1	129..183	CDD:412127	17/62 (27%)
		Protein Kinases, catalytic domain	236..537	CDD:473864	147/314 (47%)