DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc53E and PRKCQ

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	XP_005252553.1	Gene:	PRKCQ / 5588	HGNCID:	9410	Length:	740	Species:	Homo sapiens

Alignment Length:	692	Identity:	295/692 - (42%)
Similarity:	381/692 - (55%)	Gaps:	136/692 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSEGSDNNGDPQQQGAEGEAVGENKMKSRLRKGALKKKNVFNVKDHCFIARFFKQPTFCSHCKDF 65
            ||:..|.|          |...|.......|:||:|:..|.:||.|.|.|.||.||||||.|.:|
Human   159 MSDTKDMN----------EFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEF 213

  Fly    66 ICGYQSGYAWMGFGKQGFQCQVCSYVVHKRCHEYVTFICPGKDKGIDS------------DSPKT 118
            :        | |..|||:||:.|:..:||:|.:.|...|.|  ..|:|            |.|
Human   214 V--------W-GLNKQGYQCRQCNAAIHKKCIDKVIAKCTG--SAINSRETMFHKERFKIDMP-- 265

  Fly   119 QHNFEPFTYAGPTFCDHCGSLLYGIYHQGLKCSACDMNVHARCKENVPSLCGCDHTERRGRIYLE 183
             |.|:.:.|..||||:|||:||:|:..|||||.||.||||.||:..|.:|||
Human   266 -HRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCG------------- 316

  Fly   184 INVKENLLTVQIKEGRNLIPMDPNGLSDPYVKVKLIPDDKDQSKKKTRTIKACLNPVWNETLTYD 248
            ||.|      .:.|...:|                      :|.::.|    ||.
Human   317 INQK------LMAEALAMI----------------------ESTQQAR----CLR---------- 339

  Fly   249 LKPEDKDRRILIEVWDWDRTSRNDFMGALSFGISEIIKN-------PTNGWFKLLTQDEGEYYNV 306
                           |.::..|.   |.:..|:...|||       ||.|    ..:.:|..:..
Human   340 ---------------DTEQIFRE---GPVEIGLPCSIKNEARPPCLPTPG----KREPQGISWES 382

  Fly   307 PCADDEQDLLKLKQKPSQKKPMVMRSDTNTHTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKG 371
            |.  ||.|.:....:|          :.|....|.:..::..||...|:|||||||||.|||.|.
Human   383 PL--DEVDKMCHLPEP----------ELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKK 435

  Fly   372 SEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDL 436
            :.:.:|||.|||||::.||||||||:|||||:|..:.|||..:...|||.:.|||||||:|||||
Human   436 TNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDL 500

  Fly   437 MFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIV 501
            |:.||...||....|.||||||..||.|||:|||:||||||||:|||.|||:|||||||||||::
Human   501 MYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENML 565

  Fly   502 GDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNV 566
            ||..|.|||||||||||||:|.|.|..|||||::||||||||:||.||.|:||||||.:|...|.
Human   566 GDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNP 630

  Fly   567 SYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKH 631
            .||:.|.||||:.......::|.||||.    ..|:|.||.||.|:||::|.:|:.|||:||:|.
Human   631 FYPRWLEKEAKDLLVKLFVREPEKRLGV----RGDIRQHPLFREINWEELERKEIDPPFRPKVKS 691

  Fly   632 RKDVSNFDKQFTSEKTDLTPTDKVFMMNLDQSEFVGFSYMNP 673
            ..|.|||||:|.:||..|:..|:..:.::||:.|..||:|||
Human   692 PFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNP 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	28/65 (43%)
		C1_cPKC_rpt2	120..173	CDD:410386	30/52 (58%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	20/136 (15%)
		STKc_cPKC	353..672	CDD:270739	189/318 (59%)
PRKCQ	XP_005252553.1	C1_1	194..246	CDD:278556	27/62 (44%)
		C1_1	266..318	CDD:278556	30/64 (47%)
		STKc_nPKC_theta	408..738	CDD:270770	194/330 (59%)
		S_TKc	414..668	CDD:214567	161/257 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940