Protein Alignment Pkc53E and PRKCH

DIOPT Version :10

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: XP_047287541.1
• Gene: PRKCH / 5583
• HGNCID: 9403
• Length: 782
• Species: Homo sapiens
• Alignment Length: 656
• Identity: 281/656 - (42%)
• Similarity: 363/656 - (55%)
• Gaps: 139/656 - (21%)

  Fly    28 SRLRKGALKKKNVFNVKDHCFIARFFKQPTFCSHCKDFICGYQSGYAWMGFGKQGFQCQVCSYVV 92
            :|.|:.|:::: |..:..|.|:|.:.:|||:||||::||        |..|||||:|||||:.||
Human   254 TRKRQRAMRRR-VHQINGHKFMATYLRQPTYCSHCREFI--------WGVFGKQGYQCQVCTCVV 309

  Fly    93 HKRCHEYVTFICPGKD--KGIDSDSPKTQ------HNFEPFTYAGPTFCDHCGSLLYGIYHQGLK 149
            |||||..:...|..::  ..:||...:.:      |.|....|..|||||||||||:||..|||:
Human   310 HKRCHHLIVTACTCQNNINKVDSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQ 374

  Fly   150 CSACDMNVHARCKENVPSLCGCDHTERRGRIYLEINVKENLLTVQIKEGRNLIPMDPNGLSDPYV 214
            |..|.||||.||:.||...||             :|..|...|:   .|..|.|
Human   375 CKICKMNVHIRCQANVAPNCG-------------VNAVELAKTL---AGMGLQP----------- 412

  Fly   215 KVKLIPDDKDQSKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRTSRNDFMGALSF 279
                                                                        |.:|
Human   413 ------------------------------------------------------------GNIS- 416

  Fly   280 GISEIIKNPTNGWFKLLTQDEGEYYNVPCADDEQDLLKLKQKPSQKKPMVMRSDTNTHTSSKKDM 344
                    ||:   ||::               :..|:.:.|.|.|       :.|....:..:.
Human   417 --------PTS---KLVS---------------RSTLRRQGKESSK-------EGNGIGVNSSNR 448

  Fly   345 IRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPP 409
            :...:|.||:||||||||||:||..|.:.:|||:|:||||||:|||||||||.|||:|:|....|
Human   449 LGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHP 513

  Fly   410 FLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRD 474
            ||.||..||||.||||||||:||||||||.||:..:|.|..|.||||||.:.|.|||.|||:|||
Human   514 FLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRD 578

  Fly   475 LKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLL 539
            |||||||||.:||.|:||||||||.|....||.|||||||||||||:....||.:|||||.||||
Human   579 LKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLL 643

  Fly   540 YEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLG-CGSSGEEDVR 603
            ||||.|..||:.|:|::||.||.:..|.||..|.::|....|.|:||.|..||| ....||..:.
Human   644 YEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAIL 708

  Fly   604 LHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDKVFMMNLDQSEFVGF 668
            .||||:.|||.::.:|:::|||:|:||.|:||||||..|..|:..|||.|:..:..::|.||..|
Human   709 RHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNF 773

  Fly   669 SYMNPE 674
            ||::||
Human   774 SYVSPE 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	31/67 (46%)
		C1_cPKC_rpt2	120..173	CDD:410386	31/52 (60%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	12/129 (9%)
		STKc_cPKC	353..672	CDD:270739	192/319 (60%)
PRKCH	XP_047287541.1	C2_PKC_epsilon	8..122	CDD:175981
		C1_nPKC_epsilon-like_rpt1	265..325	CDD:410385	32/67 (48%)
		C1_nPKC_epsilon-like_rpt2	343..397	CDD:410388	31/66 (47%)
		STKc_nPKC_eta	458..780	CDD:270742	193/322 (60%)