Protein Alignment Pkc53E and PRKCE

DIOPT Version :10

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_005391.1
• Gene: PRKCE / 5581
• HGNCID: 9401
• Length: 737
• Species: Homo sapiens
• Alignment Length: 683
• Identity: 307/683 - (44%)
• Similarity: 408/683 - (59%)
• Gaps: 104/683 - (15%)

  Fly    15 GAEGEAVGEN-------KMKSRLRKGALKKKNVFNVKDHCFIARFFKQPTFCSHCKDFICGYQSG 72
            |:.|||..:|       :|:.|.|:||:::: |..|..|.|:|.:.:|||:||||:|||
Human   133 GSSGEAPKDNEERVFRERMRPRKRQGAVRRR-VHQVNGHKFMATYLRQPTYCSHCRDFI------ 190

  Fly    73 YAWMGFGKQGFQCQVCSYVVHKRCHEYVTFICPGKDKGIDSDSPKTQ-------HNFEPFTYAGP 130
              |...||||:|||||:.||||||||.:...|.|..|....|...:|       |.|....|..|
Human   191 --WGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVP 253

  Fly   131 TFCDHCGSLLYGIYHQGLKCSACDMNVHARCKENVPSLCGCDHTERRG--RIYLEINVKENLLTV 193
            ||||||||||:|:..|||:|..|.||||.||:.||...||.|   .||  ::..::.|..:.:|.
Human   254 TFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVD---ARGIAKVLADLGVTPDKITN 315

  Fly   194 QIKEGRNLI-----PMDPNGLSDPYVKVKLIPDDKDQSKKKTRTIKACLNPVWNETLTYDLKPED 253
            ..:..:.||     |...:|.|         |.::|:||....:                  |.|
Human   316 SGQRRKKLIAGAESPQPASGSS---------PSEEDRSKSAPTS------------------PCD 353

  Fly   254 KDRRILIEVWDWDRTSRNDFMGALSFGISEIIKNPTNGWFKLLTQDEGEYYNVPCADDEQDLLKL 318
            ::.:.|          .|:...||||                  .:.||.:....:.|.|
Human   354 QEIKEL----------ENNIRKALSF------------------DNRGEEHRAASSPDGQ----- 385

  Fly   319 KQKPSQKKPMVMRSDTNTHTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKK 383
                     ::...:.......:...:...:|||||||||||||||:|||.||.:|:||:|:|||
Human   386 ---------LMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKK 441

  Fly   384 DVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKE 448
            |||:|||||:|||.|||:|||..|.|:|.||:.||||.||||||||||||||||||||:..||.|
Human   442 DVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE 506

  Fly   449 PVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTP 513
            |.:.|||||:.:.|.|||..|::||||||||:||||:||.|:||||||||.|:...||.||||||
Human   507 PRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTP 571

  Fly   514 DYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKE 578
            |||||||:....||.||||||.|||:|||:.|||||:.::|::||.:|...:|.||..|||||..
Human   572 DYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVS 636

  Fly   579 ACKGFLTKQPNKRLGCGSS--GEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQ 641
            ..|.|:||.|:|||||.:|  ||:.::.||||:.|||..:|.::::|||||:||.::||:|||:.
Human   637 ILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQD 701

  Fly   642 FTSEKTDLTPTDKVFMMNLDQSEFVGFSYMNPE 674
            ||.|:..||..|:..:..::|.||.||||...:
Human   702 FTREEPVLTLVDEAIVKQINQEEFKGFSYFGED 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	33/65 (51%)
		C1_cPKC_rpt2	120..173	CDD:410386	30/52 (58%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	23/136 (17%)
		STKc_cPKC	353..672	CDD:270739	200/320 (63%)
PRKCE	NP_005391.1	C2_PKC_epsilon	3..135	CDD:175981	1/1 (100%)
		C1_nPKC_epsilon-like_rpt1	161..224	CDD:410385	35/71 (49%)
		Interaction with actin. /evidence=ECO:0000250	223..228		1/4 (25%)
		C1_nPKC_epsilon-like_rpt2	241..295	CDD:410388	30/53 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	325..356		9/57 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..398		4/41 (10%)
		STKc_nPKC_epsilon	412..732	CDD:270743	199/319 (62%)