DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pkc53E and PRKCE

DIOPT Version :9

Sequence 1:NP_725626.1 Gene:Pkc53E / 48311 FlyBaseID:FBgn0003091 Length:679 Species:Drosophila melanogaster
Sequence 2:NP_005391.1 Gene:PRKCE / 5581 HGNCID:9401 Length:737 Species:Homo sapiens


Alignment Length:683 Identity:307/683 - (44%)
Similarity:408/683 - (59%) Gaps:104/683 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 GAEGEAVGEN-------KMKSRLRKGALKKKNVFNVKDHCFIARFFKQPTFCSHCKDFICGYQSG 72
            |:.|||..:|       :|:.|.|:||:::: |..|..|.|:|.:.:|||:||||:|||      
Human   133 GSSGEAPKDNEERVFRERMRPRKRQGAVRRR-VHQVNGHKFMATYLRQPTYCSHCRDFI------ 190

  Fly    73 YAWMGFGKQGFQCQVCSYVVHKRCHEYVTFICPGKDKGIDSDSPKTQ-------HNFEPFTYAGP 130
              |...||||:|||||:.||||||||.:...|.|..|....|...:|       |.|....|..|
Human   191 --WGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVP 253

  Fly   131 TFCDHCGSLLYGIYHQGLKCSACDMNVHARCKENVPSLCGCDHTERRG--RIYLEINVKENLLTV 193
            ||||||||||:|:..|||:|..|.||||.||:.||...||.|   .||  ::..::.|..:.:|.
Human   254 TFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVD---ARGIAKVLADLGVTPDKITN 315

  Fly   194 QIKEGRNLI-----PMDPNGLSDPYVKVKLIPDDKDQSKKKTRTIKACLNPVWNETLTYDLKPED 253
            ..:..:.||     |...:|.|         |.::|:||....:                  |.|
Human   316 SGQRRKKLIAGAESPQPASGSS---------PSEEDRSKSAPTS------------------PCD 353

  Fly   254 KDRRILIEVWDWDRTSRNDFMGALSFGISEIIKNPTNGWFKLLTQDEGEYYNVPCADDEQDLLKL 318
            ::.:.|          .|:...||||                  .:.||.:....:.|.|     
Human   354 QEIKEL----------ENNIRKALSF------------------DNRGEEHRAASSPDGQ----- 385

  Fly   319 KQKPSQKKPMVMRSDTNTHTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKK 383
                     ::...:.......:...:...:|||||||||||||||:|||.||.:|:||:|:|||
Human   386 ---------LMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKK 441

  Fly   384 DVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKE 448
            |||:|||||:|||.|||:|||..|.|:|.||:.||||.||||||||||||||||||||:..||.|
Human   442 DVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE 506

  Fly   449 PVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTP 513
            |.:.|||||:.:.|.|||..|::||||||||:||||:||.|:||||||||.|:...||.||||||
Human   507 PRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTP 571

  Fly   514 DYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKE 578
            |||||||:....||.||||||.|||:|||:.|||||:.::|::||.:|...:|.||..|||||..
Human   572 DYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVS 636

  Fly   579 ACKGFLTKQPNKRLGCGSS--GEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQ 641
            ..|.|:||.|:|||||.:|  ||:.::.||||:.|||..:|.::::|||||:||.::||:|||:.
Human   637 ILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQD 701

  Fly   642 FTSEKTDLTPTDKVFMMNLDQSEFVGFSYMNPE 674
            ||.|:..||..|:..:..::|.||.||||...:
Human   702 FTREEPVLTLVDEAIVKQINQEEFKGFSYFGED 734

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pkc53ENP_725626.1 C1_cPKC_rpt1 44..110 CDD:410383 33/65 (51%)
C1_cPKC_rpt2 120..173 CDD:410386 30/52 (58%)
C2_PKC_alpha_gamma 177..307 CDD:175992 23/136 (17%)
STKc_cPKC 353..672 CDD:270739 200/320 (63%)
PRKCENP_005391.1 C2_PKC_epsilon 3..135 CDD:175981 1/1 (100%)
C1_nPKC_epsilon-like_rpt1 161..224 CDD:410385 35/71 (49%)
Interaction with actin. /evidence=ECO:0000250 223..228 1/4 (25%)
C1_nPKC_epsilon-like_rpt2 241..295 CDD:410388 30/53 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 325..356 9/57 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 370..398 4/41 (10%)
STKc_nPKC_epsilon 412..732 CDD:270743 199/319 (62%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149236
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51944
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000117
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R891
SonicParanoid 1 1.000 - - X125
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.880

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