Protein Alignment Pkc53E and PRKCD

DIOPT Version :9

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_001341605.1
• Gene: PRKCD / 5580
• HGNCID: 9399
• Length: 695
• Species: Homo sapiens
• Alignment Length: 678
• Identity: 278/678 - (41%)
• Similarity: 370/678 - (54%)
• Gaps: 150/678 - (22%)

  Fly    12 QQQGAEGEAVGENKMKSRLRKGALKKKNVFNVKDHCFIARFFKQPTFCSHCKDFICGYQSGYAWM 76
            |...:|.||    |..:..|:||:|:..:..:|:|.|||.||.||||||.||||:        |
Human   148 QSMRSEDEA----KFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFV--------W- 199

  Fly    77 GFGKQGFQCQVCSYVVHKRCHEYVTFICPG----------KDKGIDSDSPKTQHNFEPFTYAGPT 131
            |..|||::|:.|:..:||:|.:.:...|.|          :.:..:.|.|   |.|:...|..||
Human   200 GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMP---HRFKVHNYMSPT 261

  Fly   132 FCDHCGSLLYGIYHQGLKCSACDMNVHARCKENVPSLCGCDHTERRGRIYLEINVKENLLTVQIK 196
            |||||||||:|:..|||||..|.||||.:|:|.|.:|||
Human   262 FCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCG-------------------------- 300

  Fly   197 EGRNLIPMDPNGLSDPYVKVKLIPDDKDQSKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILIE 261
                             :..||:.:..:|..::.
Human   301 -----------------INQKLLAEALNQVTQRA------------------------------- 317

  Fly   262 VWDWDRTSRNDFMGALSFGISEIIKNPTNGWFKLLTQDEGEYYNVPCADDEQDLLKLKQKPSQKK 326
                  :.|:|...:...||.:        .|:..|...||        |.||
Human   318 ------SRRSDSASSEPVGIYQ--------GFEKKTGVAGE--------DMQD------------ 348

  Fly   327 PMVMRSDTNTHTSSK----KDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVII 387
                    |:.|..|    .......:|.|.|||||||||||||.|.||..|.:|||.|||||::
Human   349 --------NSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVL 405

  Fly   388 QDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAV 452
            .||||||||:|||||.|..:.|||..|...|||.|.||||||::||||||:.||..|:|:...|.
Human   406 IDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRAT 470

  Fly   453 FYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIA 517
            ||||||..||.|||:|||:||||||||||||.|||:||||||||||||.|:....||||||||||
Human   471 FYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIA 535

  Fly   518 PEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKG 582
            |||:....|..|||||::||||||||:||.||.|:||:|||.:|......||:.::||:|:..:.
Human   536 PEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEK 600

  Fly   583 FLTKQPNKRLGCGSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKT 647
            ...::|.||||...    ::::||||:.|:|..:|.|.::|||:||:|..:|.||||::|.:||.
Human   601 LFEREPTKRLGVTG----NIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKA 661

  Fly   648 DLTPTDKVFMMNLDQSEFVGFSYMNPEY 675
            .|:.:||..:.::|||.|.|||::||::
Human   662 RLSYSDKNLIDSMDQSAFAGFSFVNPKF 689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	29/75 (39%)
		C1_cPKC_rpt2	120..173	CDD:410386	31/52 (60%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	11/129 (9%)
		STKc_cPKC	353..672	CDD:270739	186/318 (58%)
PRKCD	NP_001341605.1	C1_1	178..227	CDD:278556	26/57 (46%)
		C1_1	250..302	CDD:278556	31/94 (33%)
		STKc_nPKC_delta	372..687	CDD:173710	186/318 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940