Protein Alignment Pkc53E and PRKCB

DIOPT Version :10

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_002729.2
• Gene: PRKCB / 5579
• HGNCID: 9395
• Length: 673
• Species: Homo sapiens
• Alignment Length: 682
• Identity: 441/682 - (64%)
• Similarity: 527/682 - (77%)
• Gaps: 35/682 - (5%)

  Fly     9 GDPQQQGAEGEAVGENKMKSRLRKGALKKKNVFNVKDHCFIARFFKQPTFCSHCKDFICGYQSGY 73
            |.|..:|.|...       ...|||||::|||..||:|.|.|||||||||||||.|||
Human     7 GPPPSEGEESTV-------RFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFI------- 57

  Fly    74 AWMGFGKQGFQCQVCSYVVHKRCHEYVTFICPGKDKGIDSDSPKTQHNFEPFTYAGPTFCDHCGS 138
             | ||||||||||||.:||||||||:|||.|||.|||..||.|:::|.|:..||:.|||||||||
Human    58 -W-GFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS 120

  Fly   139 LLYGIYHQGLKCSACDMNVHARCKENVPSLCGCDHTERRGRIYLEINVKENLLTVQIKEGRNLIP 203
            ||||:.|||:||..|.||||.||..|||||||.||||||||||::.::..::|.|.:::.:||:|
Human   121 LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVP 185

  Fly   204 MDPNGLSDPYVKVKLIPDDKDQSKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRT 268
            ||||||||||||:|||||.|.:||:||:|||..|||.||||..:.||..|||||:.:|:||||.|
Human   186 MDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLT 250

  Fly   269 SRNDFMGALSFGISEIIKNPTNGWFKLLTQDEGEYYNVPC------ADDE--QDLLKLKQKPSQK 325
            |||||||:|||||||:.|...:||||||:|:||||:|||.      |::|  |...:.|.....|
Human   251 SRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTK 315

  Fly   326 KPMVMRSDTNTHTSSK------KDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKD 384
            .|    .:..|:|.||      :|.::.|||||:.||||||||||:|:||||::||||:||||||
Human   316 VP----EEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKD 376

  Fly   385 VIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEP 449
            |:||||||||||:|||||||..|||||.||||||||||||:||||||||||||:.|||.|:||||
Human   377 VVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP 441

  Fly   450 VAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPD 514
            .|||||||||.|||||.:|||:|||||||||:||::||:||||||||||||....||||||||||
Human   442 HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPD 506

  Fly   515 YIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEA 579
            |||||||.||||||||||||:||||||||.||.||:||||:|||.:|.:|||:||||:||||...
Human   507 YIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571

  Fly   580 CKGFLTKQPNKRLGCGSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTS 644
            |||.:||.|.||||||..||.|::.|.|||.|||||:|.:|:|||:|||...| :..|||:.||.
Human   572 CKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDRFFTR 635

  Fly   645 EKTDLTPTDKVFMMNLDQSEFVGFSYMNPEYV 676
            ....|||.|:..:.|:|||||.|||::|.|::
Human   636 HPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFL 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	47/65 (72%)
		C1_cPKC_rpt2	120..173	CDD:410386	36/52 (69%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	82/129 (64%)
		STKc_cPKC	353..672	CDD:270739	233/318 (73%)
PRKCB	NP_002729.2	C1_cPKC_rpt1	35..92	CDD:410383	47/65 (72%)
		C1_cPKC_rpt2	102..155	CDD:410386	36/52 (69%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	82/129 (64%)
		STKc_cPKC_beta	341..663	CDD:270767	237/322 (74%)