DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc53E and prkcq

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	XP_009298659.1	Gene:	prkcq / 555521	ZFINID:	ZDB-GENE-041210-195	Length:	719	Species:	Danio rerio

Alignment Length:	695	Identity:	289/695 - (41%)
Similarity:	392/695 - (56%)	Gaps:	131/695 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EGSDNNGDPQQQGAEGEAVGENKMKSRLRKGALKKKNVFNVKDHCFIARFFKQPTFCSHCKDFIC 67
            |.||..|..:..| |.|...|.......|:||:|:..|..||.|.|.|.||.||||||.||:|:
Zfish   124 ERSDAAGHGEGDG-ETEREKEGVFALHHRRGAIKQAKVHVVKCHEFTATFFPQPTFCSVCKEFV- 186

  Fly    68 GYQSGYAWMGFGKQGFQCQVCSYVVHKRCHEYVTFICPG-----KDKGIDSDSPKTQ--HNFEPF 125
                   | |..|||:||:.|:..:||:|.:.|...|.|     |:..|..:..|..  |.|:.:
Zfish   187 -------W-GLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAVNSKETMIHKERFKIDMPHRFKVY 243

  Fly   126 TYAGPTFCDHCGSLLYGIYHQGLKCSACDMNVHARCKENVPSLCG------------CDHTERRG 178
            .|..||||:|||:||:|:..|||||..|.||||.:|::.|.:|||            .:.|:::.
Zfish   244 NYMSPTFCEHCGTLLWGLARQGLKCEECGMNVHHKCQKKVANLCGVNQKLMAEALAMIESTQQQA 308

  Fly   179 RIYLEINVKENLLTVQIKEGRNLIPM---DPNGLSDPYVKVKLIPDDKDQSKKKTRTIKACLNPV 240
            |      ...:..||. :||    |:   .|..:.:|..::.:.|                |.|.
Zfish   309 R------SSRDTETVG-REG----PVSADQPGVIREPSGRLAISP----------------LTPA 346

  Fly   241 WNETLTYDLKPEDKDRRILIEVWDWDRTSRNDFMGALSFGISEIIKNPTNGWFKLLTQDEGEYYN 305
                   ...|..:.:.|     .||                    :|.:|
Zfish   347 -------PPLPRKEHQGI-----SWD--------------------SPADG-------------- 365

  Fly   306 VPCADDEQDLLKLKQKPSQKKPMVMRSDTNTHTSSKKDMIRATDFNFI--KVLGKGSFGKVLLAE 368
                          ::||.::|..:      :.:.:|:..:.|..:||  |:|||||||||.|||
Zfish   366 --------------RRPSLEEPEPL------YATPRKEHHKFTIDSFILHKMLGKGSFGKVFLAE 410

  Fly   369 RKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNG 433
            .|||.:.:|:|.|||||::.||||||||:|:|||:|....|||..|:..|||.:.|||||||:||
Zfish   411 LKGSGQFFAVKALKKDVVLMDDDVECTMVERRVLSLAWDHPFLTHLYCTFQTKENLFFVMEYLNG 475

  Fly   434 GDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKE 498
            |||||.||...:|..|.:.||||||..||.|||:|||:||||||||:|||.|||:||||||||||
Zfish   476 GDLMFHIQTCHRFDLPRSTFYAAEIICGLQFLHSKGIVYRDLKLDNILLDTDGHIKIADFGMCKE 540

  Fly   499 NIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITD 563
            ||:|:..|.|||||||||||||:|.|.||.|||||::||||||||:||.||.|.||||||.:|..
Zfish   541 NIIGEARTCTFCGTPDYIAPEILLGQKYGTSVDWWSFGVLLYEMLIGQSPFHGHDEEELFQSIRT 605

  Fly   564 HNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPK 628
            .:..||:.|:::|::.......::|.:|||.    :.::|.|||||..||..:|.|:|:|||||.
Zfish   606 DDPCYPRWLTRDARDILVKLFVREPERRLGV----KGNIRQHPFFRETDWSALEERQVEPPFKPT 666

  Fly   629 IKHRKDVSNFDKQFTSEKTDLTPTDKVFMMNLDQSEFVGFSYMNP 673
            :|...|.|||||:|.:||..|:.||::.:.::|||.|..||::||
Zfish   667 VKSANDCSNFDKEFINEKPRLSVTDRMMINSMDQSMFENFSFINP 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	30/70 (43%)
		C1_cPKC_rpt2	120..173	CDD:410386	28/64 (44%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	17/132 (13%)
		STKc_cPKC	353..672	CDD:270739	189/320 (59%)
prkcq	XP_009298659.1	C1_1	166..218	CDD:278556	27/60 (45%)
		C1_1	238..290	CDD:278556	28/51 (55%)
		STKc_nPKC_theta	386..716	CDD:270770	193/330 (58%)
		S_TKc	392..646	CDD:214567	158/257 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.940