DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pkc53E and Lats2

DIOPT Version :10

Sequence 1:NP_725626.1 Gene:Pkc53E / 48311 FlyBaseID:FBgn0003091 Length:679 Species:Drosophila melanogaster
Sequence 2:NP_056586.2 Gene:Lats2 / 50523 MGIID:1354386 Length:1042 Species:Mus musculus


Alignment Length:546 Identity:153/546 - (28%)
Similarity:245/546 - (44%) Gaps:123/546 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   188 ENLLTVQIKEGRNLIPMDPNGLS-----DPYVKVKLIP--------------------------- 220
            |:|.|.:...|.:.:.:|..|..     .||.|..|:|                           
Mouse   445 ESLETKEGSAGPHPLDVDYGGSERRCPPPPYPKHLLLPSKSEQYSVDLDSLCTSVQQSLRGGTEQ 509

  Fly   221 DDKDQSKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRTSRNDFMG--ALSFGISE 283
            |..|:|.|..:..||..:....:|....::...:|..        .|.||.....  |..|.:.:
Mouse   510 DRSDKSHKGAKGDKAGRDKKQIQTSPVPVRKNSRDEE--------KRESRIKSYSPYAFKFFMEQ 566

  Fly   284 IIKNPTNGWFKLLT---QDEGEYYNVPCADDEQDLLKLKQKPSQKKPMVMRSDTNTHTSSKKDMI 345
            .::|....:.:.::   |.|.|.......:.||:         |.:.::.:.::|.:...:..|.
Mouse   567 HVENVIKTYQQKVSRRLQLEQEMAKAGLCEAEQE---------QMRKILYQKESNYNRLKRAKMD 622

  Fly   346 RATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPF 410
            ::. |..||.||.|:||:|.||.:..:..|||:|.|:|..::..:.|.....|:.:||..:. .:
Mouse   623 KSM-FVKIKTLGIGAFGEVCLACKLDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADN-EW 685

  Fly   411 LVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDL 475
            :|:|:..||..|.|:|||:|:.|||:|..:.:...|.|.:|.||.||:...:..:|..|.::||:
Mouse   686 VVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDI 750

  Fly   476 KLDNVLLDADGHVKIADFGMC-------------KENIV-------------------GD--KTT 506
            |.||:|:|.|||:|:.|||:|             |.|.:                   ||  ||.
Mouse   751 KPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGNHMRQDSMEPGDLWDDVSNCRCGDRLKTL 815

  Fly   507 K-------------TFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPF--DGEDEEE 556
            :             :..|||:|||||::|.:.|.:..|||:.||:|:|||||||||  ....|.:
Mouse   816 EQRAQKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQ 880

  Fly   557 LFAAITDHNVSYPKS--LSKEAKEACKGFLTKQPNKRLGC------GSSGEEDVRLHPFFRRIDW 613
            |.....:..:..|..  ||.||::    .:||     |.|      |..|.:|::.||||..||:
Mouse   881 LKVINWESTLHIPTQVRLSAEARD----LITK-----LCCAADCRLGRDGADDLKAHPFFNTIDF 936

  Fly   614 EKIENREVQPPFKPKIKHRKDVSNFD 639
            .: :.|:...|:.|.|.|..|.||||
Mouse   937 SR-DIRKQPAPYVPTISHPMDTSNFD 961

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pkc53ENP_725626.1 C1_cPKC_rpt1 44..110 CDD:410383
C1_cPKC_rpt2 120..173 CDD:410386
C2_PKC_alpha_gamma 177..307 CDD:175992 28/155 (18%)
STKc_cPKC 353..672 CDD:270739 119/344 (35%)
Lats2NP_056586.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 23..44
Interaction with ubiquitinated AMOTL2. /evidence=ECO:0000250|UniProtKB:Q9NRM7 100..140
UBA_LATS2 100..140 CDD:270581
PHA03247 <150..513 CDD:223021 12/67 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 237..282
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 378..399
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 442..481 9/35 (26%)
PPxY motif 472..475 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..550 9/56 (16%)
MobB_LATS2 543..625 CDD:439272 15/98 (15%)
Protein Kinases, catalytic domain 624..1004 CDD:473864 120/350 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1014..1042
Blue background indicates that the domain is not in the aligned region.

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