Protein Alignment Pkc53E and prkci

DIOPT Version :10

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_001012707.1
• Gene: prkci / 503517
• XenbaseID: XB-GENE-481945
• Length: 588
• Species: Xenopus tropicalis
• Alignment Length: 673
• Identity: 223/673 - (33%)
• Similarity: 308/673 - (45%)
• Gaps: 206/673 - (30%)

  Fly    11 PQQQGAEGEAVGENKMKSRLRKGALKKKNVFNVKDHCFIARFFKQPTFCSHCKDFICGYQSGYAW 75
            |::.|.  ...||:  ||..|:||.:.:.::....|.|.|:.|.:...|:.|.|.|        |
 Frog   103 PERPGM--PCAGED--KSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRI--------W 155

  Fly    76 MGFGKQGFQCQVCSYVVHKRCHEYVTFICPGKDKGIDSDSPKTQHNFEPFTYAGPTFCDHCGSLL 140
             |.|:||::|..|..:|||:||:.|:..| |:                 .|.|.|
 Frog   156 -GLGRQGYKCINCKLLVHKKCHKLVSIEC-GR-----------------HTIAEP---------- 191

  Fly   141 YGIYHQGLKCSACDMNVHARCKENVPSLCGCDHTERRGRIYLEINVKENLLTVQIKEGRNLIPMD 205
                                                                        :||||
 Frog   192 ------------------------------------------------------------VIPMD 196

  Fly   206 PNGLSDPYVKVKLIPDDKDQSKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRTSR 270
            |.|:            ..|.|:               ..|.|  :|..:|
 Frog   197 PPGM------------HSDHSE---------------PXLPY--RPRSQD--------------- 217

  Fly   271 NDFMGALSFGISEIIKNPTNGWFKLLTQDEGEYYNVPCADDEQDLLKLKQKPSQKKPMVMRSDTN 335
                                                          .|.|...:|:.|..|....
 Frog   218 ----------------------------------------------NLDQVGEEKEAMNSRESGK 236

  Fly   336 THTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKR 400
            |.:|     :...||:.::|:|:||:.||||...|.:|.:||:|::||:::..|:|::....||.
 Frog   237 TPSS-----LGLQDFDLMRVIGRGSYAKVLLVRLKKTERIYAMKVVKKELVNDDEDIDWVQTEKH 296

  Fly   401 VLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFL 465
            |.......||||.|||||||..|||||:||||||||||.:|:..|..|..|.||:|||:..|.:|
 Frog   297 VFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYL 361

  Fly   466 HTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSV 530
            |.:||:||||||||||||::||:|:.|:|||||.:....||.||||||:||||||:..:.||.||
 Frog   362 HERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSV 426

  Fly   531 DWWAYGVLLYEMLVGQPPF---------DGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTK 586
            ||||.|||::||:.|:.||         |...|:.||..|.:..:..|:|||.:|....|.||.|
 Frog   427 DWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDFLFQVILEKQIRIPRSLSVKAASVLKSFLNK 491

  Fly   587 QPNKRLGC-GSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLT 650
            .|..|||| ..:|..|::.|.|||.:||:.:|.::|.|||||.|.....:.|||.|||:|...||
 Frog   492 DPKDRLGCHPQTGFADIQGHQFFRNVDWDLMEQKQVVPPFKPNISGEFGLDNFDAQFTNEPVQLT 556

  Fly   651 PTDKVFMMNLDQSEFVGFSYMNP 673
            |.|:..:..:|||||.||.|:||
 Frog   557 PDDEDVVRKIDQSEFEGFEYINP 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	23/65 (35%)
		C1_cPKC_rpt2	120..173	CDD:410386	3/52 (6%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	12/129 (9%)
		STKc_cPKC	353..672	CDD:270739	165/328 (50%)
prkci	NP_001012707.1	PB1_aPKC	19..101	CDD:99725
		C1_aPKC	132..186	CDD:410344	23/80 (29%)
		STKc_aPKC_iota	225..588	CDD:270769	174/360 (48%)