DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc53E and Akt1

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster

Alignment Length:	449	Identity:	181/449 - (40%)
Similarity:	261/449 - (58%)	Gaps:	30/449 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 TIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRTSRNDFMGALSFGI-----SEIIKNPTNG 291
            |::.|      :.:|.| :|  |....:|....|.......|  |:...:     :|.|:|.::
  Fly   159 TVRGC------QIMTVD-RP--KPFTFIIRGLQWTTVIERTF--AVESELERQQWTEAIRNVSS- 211

  Fly   292 WFKLLTQDEGEYYNVPCADDEQ---DLLKLKQKPSQKKPMVMRSDTNTHTSSKKDMIRATDFNFI 353
              :|:  |.||....|....:.   |:..:.:....::..|..:..|   ||....:...:|.|:
  Fly   212 --RLI--DVGEVAMTPSEQTDMTDVDMATIAEDELSEQFSVQGTTCN---SSGVKKVTLENFEFL 269

  Fly   354 KVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCF 418
            ||||||:||||:|...|.:.:|||||||||:||||.|:|..|:.|.|||. ....|||:.|...|
  Fly   270 KVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLK-STNHPFLISLKYSF 333

  Fly   419 QTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLD 483
            ||.|||.|||:|||||:|.:.:.....|.|....||.|||.:.|.:||::||:||||||:|:|||
  Fly   334 QTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLD 398

  Fly   484 ADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPP 548
            .|||:|:||||:|||:|...:|||||||||:|:|||::....||::||||..||::|||:.|:.|
  Fly   399 KDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLP 463

  Fly   549 FDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFFRRIDW 613
            |...|.:.||..|....|.:|::::.|||....|.|.|.|.||||.|....::::.||||..|:|
  Fly   464 FYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINW 528

  Fly   614 EKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDKVFMMN--LDQSEFVGFSY 670
            ..:..:::.|||||::....|...|||:||.|..:|||.|....:.  .::..|..|||
  Fly   529 TDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIAEEPLFPQFSY 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992	17/79 (22%)
		STKc_cPKC	353..672	CDD:270739	156/320 (49%)
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947	13/68 (19%)
		PH	107..211	CDD:278594	13/62 (21%)
		S_TKc	266..523	CDD:214567	134/257 (52%)
		STKc_PKB	270..590	CDD:270723	156/319 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	206	1.000	Inparanoid score	I1276
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D27201at7147
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.070