DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pkc53E and Akt

DIOPT Version :10

Sequence 1:NP_725626.1 Gene:Pkc53E / 48311 FlyBaseID:FBgn0003091 Length:679 Species:Drosophila melanogaster
Sequence 2:NP_732113.3 Gene:Akt / 41957 FlyBaseID:FBgn0010379 Length:611 Species:Drosophila melanogaster


Alignment Length:449 Identity:181/449 - (40%)
Similarity:261/449 - (58%) Gaps:30/449 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly   232 TIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRTSRNDFMGALSFGI-----SEIIKNPTNG 291
            |::.|      :.:|.| :|  |....:|....|.......|  |:...:     :|.|:|.:: 
  Fly   159 TVRGC------QIMTVD-RP--KPFTFIIRGLQWTTVIERTF--AVESELERQQWTEAIRNVSS- 211

  Fly   292 WFKLLTQDEGEYYNVPCADDEQ---DLLKLKQKPSQKKPMVMRSDTNTHTSSKKDMIRATDFNFI 353
              :|:  |.||....|....:.   |:..:.:....::..|..:..|   ||....:...:|.|:
  Fly   212 --RLI--DVGEVAMTPSEQTDMTDVDMATIAEDELSEQFSVQGTTCN---SSGVKKVTLENFEFL 269

  Fly   354 KVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCF 418
            ||||||:||||:|...|.:.:|||||||||:||||.|:|..|:.|.|||. ....|||:.|...|
  Fly   270 KVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLK-STNHPFLISLKYSF 333

  Fly   419 QTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLD 483
            ||.|||.|||:|||||:|.:.:.....|.|....||.|||.:.|.:||::||:||||||:|:|||
  Fly   334 QTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLD 398

  Fly   484 ADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPP 548
            .|||:|:||||:|||:|...:|||||||||:|:|||::....||::||||..||::|||:.|:.|
  Fly   399 KDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLP 463

  Fly   549 FDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFFRRIDW 613
            |...|.:.||..|....|.:|::::.|||....|.|.|.|.||||.|....::::.||||..|:|
  Fly   464 FYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINW 528

  Fly   614 EKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDKVFMMN--LDQSEFVGFSY 670
            ..:..:::.|||||::....|...|||:||.|..:|||.|....:.  .::..|..|||
  Fly   529 TDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIAEEPLFPQFSY 587

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pkc53ENP_725626.1 C1_cPKC_rpt1 44..110 CDD:410383
C1_cPKC_rpt2 120..173 CDD:410386
C2_PKC_alpha_gamma 177..307 CDD:175992 17/79 (22%)
STKc_cPKC 353..672 CDD:270739 156/320 (49%)
AktNP_732113.3 PH_PKB 105..214 CDD:269947 13/68 (19%)
STKc_PKB 270..590 CDD:270723 156/319 (49%)
Blue background indicates that the domain is not in the aligned region.

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