DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkc53E and dop

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_001261884.1	Gene:	dop / 39686	FlyBaseID:	FBgn0267390	Length:	2139	Species:	Drosophila melanogaster

Alignment Length:	366	Identity:	125/366 - (34%)
Similarity:	196/366 - (53%)	Gaps:	35/366 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   334 TNTHTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIE 398
            |.|.:.:::...:..||:.:|::..|::|.|.|.:.|.:.:.:|:|.:.|:.:|..:.||....|
  Fly   819 TATGSGAQQPSPQENDFDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAE 883

  Fly   399 KRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLF 463
            :.:|:..:. ||:|.::..|:|...|..|||||.|||....::..|.....:|.||.||....:.
  Fly   884 RDILSFADN-PFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPADMARFYFAETVLAVE 947

  Fly   464 FLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVG----------DKTTKTFC-----GTP 513
            :||:.||::||||.||:|:.|.||:|:.|||:.|..::.          |..|:.|.     |||
  Fly   948 YLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTP 1012

  Fly   514 DYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKS----LSK 574
            :|||||:||.|.|||.||||:.|::|||.|:|..||.||..|||||...:.::.:|.|    :..
  Fly  1013 EYIAPEVILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQA 1077

  Fly   575 EAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFD 639
            |||:.....|.:.|..|||. .||..:::.|.:|..:||..:..::.:  |.|::.|..|.|.||
  Fly  1078 EAKDIISQLLQQNPRDRLGT-QSGALEMKEHEYFLGMDWNSLLRQKAE--FVPQLSHDDDTSYFD 1139

  Fly   640 KQFTSEKTDL-----TPTDKVFMMNLDQSEFVGFSYMNPEY 675
            .:......||     ..||       |...|..|:...|:|
  Fly  1140 TRMDRYNHDLGGEDTDDTD-------DTPVFGSFNSYTPQY 1173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992
		STKc_cPKC	353..672	CDD:270739	119/342 (35%)
dop	NP_001261884.1	DUF1908	344..702	CDD:286070
		STKc_MAST	834..1115	CDD:270760	105/282 (37%)
		S_TKc	835..1110	CDD:214567	103/276 (37%)
		PDZ_signaling	1506..1587	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24356
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100