DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc53E and akt2

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_937789.1	Gene:	akt2 / 378972	ZFINID:	ZDB-GENE-031007-5	Length:	479	Species:	Danio rerio

Alignment Length:	336	Identity:	149/336 - (44%)
Similarity:	217/336 - (64%)	Gaps:	5/336 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 SSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLA 403
            :..:..:..:||:::|:||||:||||:|...|.:...||:|||:|:|||..|:|..|:.|.|||.
Zfish   139 TKSRTKVTMSDFDYLKLLGKGTFGKVILVREKATGMYYAMKILRKEVIIAKDEVAHTITESRVLQ 203

  Fly   404 LGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTK 468
             ..:.|||..|...|||.|||.|||||.|||:|.|.:.:...|.|..|.||.|||.:.|.:||:|
Zfish   204 -NTRHPFLTTLKYAFQTRDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSALEYLHSK 267

  Fly   469 GILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWW 533
            .::||||||:|::||.|||:||.|||:|||.|..:.|.|||||||:|:|||::....||::||||
Zfish   268 DVVYRDLKLENLMLDKDGHIKITDFGLCKEGITNEATMKTFCGTPEYLAPEVLEDNDYGRAVDWW 332

  Fly   534 AYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSG 598
            ..||::|||:.|:.||..:|.|.||..|....:.:|::||.|||....|.|.|.|.:|||.|...
Zfish   333 GLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRNLSPEAKALLAGLLKKDPKQRLGGGPED 397

  Fly   599 EEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDKVFMMNLD-- 661
            .::|..|.||..::|:.:..:::.|||||::....|...||.:||::...:||.|:...::.:
Zfish   398 AKEVMTHKFFNNMNWQDVLQKKLVPPFKPQVTSETDTRYFDDEFTAQTITVTPPDQYDSLDAEDP 462

  Fly   662 --QSEFVGFSY 670
              ::.|..|||
Zfish   463 DTRTHFSQFSY 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992
		STKc_cPKC	353..672	CDD:270739	147/322 (46%)
akt2	NP_937789.1	PH_PKB	4..111	CDD:269947
		PH	6..106	CDD:278594
		S_TKc	150..407	CDD:214567	128/257 (50%)
		STKc_PKB_beta	154..476	CDD:173686	147/321 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920