DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc53E and pkn3

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	XP_003198687.2	Gene:	pkn3 / 323182	ZFINID:	ZDB-GENE-030131-1902	Length:	940	Species:	Danio rerio

Alignment Length:	397	Identity:	176/397 - (44%)
Similarity:	241/397 - (60%)	Gaps:	18/397 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 SFGISEIIK------NPTNGWFKLLTQDEGEYYNVPCADDEQDLLKLKQKPSQKKPMVMRSDTNT 336
            |.|.|.::|      .||......|.|:       |.||:.......:...::.:.::.....:.
Zfish   543 STGDSAVVKLNFSEERPTKPPRLHLAQN-------PSADESLSGTPARVNSTEDRRVLQARPASQ 600

  Fly   337 HTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRV 401
            .|..:|:.::..|||.|.|||:|.||||||||.|.:.:|||||.|||..::..|:|:..|.|||:
Zfish   601 PTPQRKEGMQMEDFNCISVLGRGHFGKVLLAEFKRTGKLYAIKALKKGDVVTRDEVDSLMCEKRI 665

  Fly   402 LAL--GEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFF 464
            ...  ..:.||||.|:.||||.|.:.|||||..|||||..|.. ..|.|..|.||:|.:..||.|
Zfish   666 FETINASRHPFLVNLYGCFQTPDHVCFVMEYSPGGDLMTHIHN-NIFSERQARFYSACVLLGLEF 729

  Fly   465 LHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENI-VGDKTTKTFCGTPDYIAPEIILYQPYGK 528
            ||...|:||||||||:|:|:||.|:|||||:|||.: .||:|: ||||||:::|||::....|.:
Zfish   730 LHQNRIVYRDLKLDNLLMDSDGFVRIADFGLCKEGMGYGDRTS-TFCGTPEFLAPEVLTDSNYTR 793

  Fly   529 SVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLG 593
            :||||..|||:||||||:.||.|:||||:|.:|.:..|.||:.:|.|:....:..|.|...||||
Zfish   794 AVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFMSPESVSVIQKLLQKNSEKRLG 858

  Fly   594 CGSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDKVFMM 658
            .|.....:|:.|.||:.||||.:..:.|:|||.|.||...||||||::||..|..|||....|.:
Zfish   859 AGEQDANEVKKHRFFQGIDWEALLAKRVKPPFLPSIKTAADVSNFDEEFTRLKPVLTPPQTPFFL 923

  Fly   659 NLDQSEF 665
            :.:|.||
Zfish   924 SAEQQEF 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992	8/34 (24%)
		STKc_cPKC	353..672	CDD:270739	160/316 (51%)
pkn3	XP_003198687.2	HR1_PKN_1	25..90	CDD:212012
		HR1	111..183	CDD:320753
		HR1_PKN3_3	199..271	CDD:212027
		C2_PKN-like	379..462	CDD:176069
		STKc_PKN	614..938	CDD:270741	162/319 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583307
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.960