DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pkc53E and PKN3

DIOPT Version :9

Sequence 1:NP_725626.1 Gene:Pkc53E / 48311 FlyBaseID:FBgn0003091 Length:679 Species:Drosophila melanogaster
Sequence 2:XP_006717143.1 Gene:PKN3 / 29941 HGNCID:17999 Length:896 Species:Homo sapiens


Alignment Length:582 Identity:198/582 - (34%)
Similarity:281/582 - (48%) Gaps:122/582 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   132 FCDH-CGSLLYGIYHQGL---KCSACDMNVHARCKENVPSLCGCDHTERRGRIYLEINVKENLLT 192
            |.|: |..|...:..|||   :.:.||..:..|     |.|      :|:.||:.:...::.|..
Human   398 FLDNACHQLSLSLVPQGLLF
AQVTFCDPVIERR-----PRL------QRQERIFSKRRGQDFLRA 451

  Fly   193 VQIKEG--------RNLIP--------MDPNG----------LSDPYVKVKLIPDDKDQSKKKTR 231
            .|:..|        .||:|        ..|.|          .|||......:|       ||| 
Human   452 SQMNLGMAAWGRLVMNLLPPCSSPSTISPPKGCPRTPTTLREASDPATPSNFLP-------KKT- 508

  Fly   232 TIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRTSRNDFMGALSFGISEIIKNPTNGWFKLL 296
                   |:..|     :.|..|..|:.:.                        :.||:      
Human   509 -------PLGEE-----MTPPPKPPRLYLP------------------------QEPTS------ 531

  Fly   297 TQDEGEYYNVPCADDEQDLLKLKQKPSQKKPMV---MRSDTNTHTSSKKDMIRATDFNFIKVLGK 358
                                  ::.|..|:|.:   .|...:...|..:...|..||..:.|||:
Human   532 ----------------------EETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGR 574

  Fly   359 GSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVL-ALG-EKPPFLVQLHSCFQTM 421
            |.||||||.:.||:.:.||||.|||..::..|::|....|||:| |:| ...|||:.|.:||||.
Human   575 GHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTS 639

  Fly   422 DRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADG 486
            ....||.|:|.|||||.||.: ..|.||.|.||.|.:..||.|||.|.|:||||||||:||||.|
Human   640 SHACFVTEFVPGGDLMMQIHE-DVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQG 703

  Fly   487 HVKIADFGMCKENI-VGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFD 550
            .:||||||:|||.| .||:|: ||||||:::|||::..:.|.::||||..||||||||||:.||.
Human   704 FLKIADFGLCKEGIGFGDRTS-TFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFP 767

  Fly   551 GEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFFRRIDWEK 615
            |:.|||:|..|.:.:..||..||.:..|..:..|.|.|.||||.|....|::::.||||..:|:.
Human   768 GDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQA 832

  Fly   616 IENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDKVFMMNL-DQSEFVGFSYMNPEYV 676
            :..|.:||||.|.:....|:..|:.:||.....|||.....::.. .|:.|..|.:::..::
Human   833 LLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFL 894

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pkc53ENP_725626.1 C1_cPKC_rpt1 44..110 CDD:410383
C1_cPKC_rpt2 120..173 CDD:410386 12/44 (27%)
C2_PKC_alpha_gamma 177..307 CDD:175992 24/155 (15%)
STKc_cPKC 353..672 CDD:270739 153/322 (48%)
PKN3XP_006717143.1 HR1_PKN_1 20..85 CDD:212012
HR1_PKN3_2 104..177 CDD:212022
HR1 177..237 CDD:294066
C2 335..417 CDD:301316 7/18 (39%)
STKc_PKN 566..891 CDD:270741 154/326 (47%)
S_TKc 566..825 CDD:214567 134/260 (52%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149230
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R891
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.870

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