DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc53E and Akt3

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	XP_038946556.1	Gene:	Akt3 / 29414	RGDID:	62390	Length:	504	Species:	Rattus norvegicus

Alignment Length:	289	Identity:	138/289 - (47%)
Similarity:	193/289 - (66%)	Gaps:	4/289 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 DTNTHTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMI 397
            |.:|....:|.|   .||:::|:||||:||||:|...|.|.:.||:|||||:|||..|:|..|:.
  Rat   157 DASTTHHKRKTM---NDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLT 218

  Fly   398 EKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGL 462
            |.|||. ..:.|||..|...|||.|||.|||||||||:|.|.:.:...|.|....||.|||.:.|
  Rat   219 ESRVLK-NTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSAL 282

  Fly   463 FFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYG 527
            .:||:..|:||||||:|::||.|||:||.|||:|||.|....|.|||||||:|:|||::....||
  Rat   283 DYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYG 347

  Fly   528 KSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRL 592
            ::||||..||::|||:.|:.||..:|.|:||..|...::.:|::||.:||....|.|.|.|||||
  Rat   348 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRL 412

  Fly   593 GCGSSGEEDVRLHPFFRRIDWEKIENREV 621
            |.|....:::..|.||..::|:.:.::::
  Rat   413 GGGPDDAKEIMRHSFFSGVNWQDVYDKKM 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992
		STKc_cPKC	353..672	CDD:270739	132/269 (49%)
Akt3	XP_038946556.1	PH_PKB	4..133	CDD:269947
Akt3	XP_038946556.1	PKc_like	175..442	CDD:419665	132/268 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920