Protein Alignment Pkc53E and Prkce

DIOPT Version :10

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_058867.2
• Gene: Prkce / 29340
• RGDID: 61925
• Length: 737
• Species: Rattus norvegicus
• Alignment Length: 683
• Identity: 305/683 - (44%)
• Similarity: 404/683 - (59%)
• Gaps: 104/683 - (15%)

  Fly    15 GAEGEAVGEN-------KMKSRLRKGALKKKNVFNVKDHCFIARFFKQPTFCSHCKDFICGYQSG 72
            |:.|||..:|       :|:.|.|:||:::: |..|..|.|:|.:.:|||:||||:|||
  Rat   133 GSSGEAPKDNEERVFRERMRPRKRQGAVRRR-VHQVNGHKFMATYLRQPTYCSHCRDFI------ 190

  Fly    73 YAWMGFGKQGFQCQVCSYVVHKRCHEYVTFICPGKDKGIDSDSPKTQ-------HNFEPFTYAGP 130
              |...||||:|||||:.||||||||.:...|.|..|....|...:|       |.|....|..|
  Rat   191 --WGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDEVGSQRFSVNMPHKFGIHNYKVP 253

  Fly   131 TFCDHCGSLLYGIYHQGLKCSACDMNVHARCKENVPSLCGCDHTERRG--RIYLEINVKENLLTV 193
            ||||||||||:|:..|||:|..|.||||.||:.||...||.|   .||  ::..::.|..:.:|.
  Rat   254 TFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVD---ARGIAKVLADLGVTPDKITN 315

  Fly   194 QIKEGRNLI-----PMDPNGLSDPYVKVKLIPDDKDQSKKKTRTIKACLNPVWNETLTYDLKPED 253
            ..:..:.|.     |...:|.|         |.:.|:||....:                  |.|
  Rat   316 SGQRRKKLAAGAESPQPASGNS---------PSEDDRSKSAPTS------------------PCD 353

  Fly   254 KDRRILIEVWDWDRTSRNDFMGALSFGISEIIKNPTNGWFKLLTQDEGEYYNVPCADDEQDLLKL 318
            ::.:.|          .|:...||||                  .:.||.:....:.|.|
  Rat   354 QELKEL----------ENNIRKALSF------------------DNRGEEHRASSSTDGQ----- 385

  Fly   319 KQKPSQKKPMVMRSDTNTHTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKK 383
                     :....:.......:...:...:|||||||||||||||:|||.||.:|:||:|:|||
  Rat   386 ---------LASPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKK 441

  Fly   384 DVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKE 448
            |||:|||||:|||.|||:|||..|.|:|.||:.||||.||||||||||||||||||||:..||.|
  Rat   442 DVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE 506

  Fly   449 PVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTP 513
            |.:.|||||:.:.|.|||..|::||||||||:||||:||.|:||||||||.|:...||.||||||
  Rat   507 PRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTP 571

  Fly   514 DYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKE 578
            |||||||:....||.||||||.|||:|||:.|||||:.::|::||.:|...:|.||..|||||..
  Rat   572 DYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVS 636

  Fly   579 ACKGFLTKQPNKRLGC--GSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQ 641
            ..|.|:||.|:|||||  ..:||:.::.||||:.|||..:|.::::|||||:||.::||:|||:.
  Rat   637 ILKAFMTKNPHKRLGCVAAQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQD 701

  Fly   642 FTSEKTDLTPTDKVFMMNLDQSEFVGFSYMNPE 674
            ||.|:..||..|:..:..::|.||.||||...:
  Rat   702 FTREEPILTLVDEAIVKQINQEEFKGFSYFGED 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	33/65 (51%)
		C1_cPKC_rpt2	120..173	CDD:410386	30/52 (58%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	22/136 (16%)
		STKc_cPKC	353..672	CDD:270739	199/320 (62%)
Prkce	NP_058867.2	C2_PKC_epsilon	3..135	CDD:175981	1/1 (100%)
		C1_nPKC_epsilon-like_rpt1	161..224	CDD:410385	35/71 (49%)
		Interaction with actin. /evidence=ECO:0000250	223..228		1/4 (25%)
		C1_nPKC_epsilon-like_rpt2	241..295	CDD:410388	30/53 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	310..356		11/72 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	369..398		5/60 (8%)
		STKc_nPKC_epsilon	412..732	CDD:270743	198/319 (62%)