DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pkc53E and Pkn3

DIOPT Version :10

Sequence 1:NP_725626.1 Gene:Pkc53E / 48311 FlyBaseID:FBgn0003091 Length:679 Species:Drosophila melanogaster
Sequence 2:XP_030107417.1 Gene:Pkn3 / 263803 MGIID:2388285 Length:914 Species:Mus musculus


Alignment Length:568 Identity:194/568 - (34%)
Similarity:279/568 - (49%) Gaps:94/568 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   132 FCDH-CGSLLYGIYHQG---LKCSACDMNVHARCKENVPSL--CGCDHTERRGRIYLEINVKENL 190
            |.|: |..|...:..||   .:.:.|:..:..|     |.|  ..|..::||||.::..:.....
Mouse   420 FLDNACHQLSLSLVPQGRLFAQVTFCEPVIERR-----PRLQRQRCIFSKRRGRDFMRASQMNLS 479

  Fly   191 LTVQIKEGRNLIP--MDPNGLSDPYVKVKLIPDDKDQSKKKTRTIKACLNP--------VWNETL 245
            :....:...:|:|  ..||..|.|               |...:...|..|        :..:||
Mouse   480 MAAWGRLVMSLLPPCSSPNTASPP---------------KGRPSTAVCGTPSAASPSNFLPMKTL 529

  Fly   246 T-YDLKPEDKDRRILIEVWDWDRTSRNDFMGALSFGISEIIKNPTNGWFKLLTQDEGEYYNVPCA 309
            : .|.||..|..|:.::                         .|..|              .||.
Mouse   530 SKEDTKPPPKPPRLYLQ-------------------------EPAPG--------------TPCT 555

  Fly   310 DDEQDLLKLKQKPSQKKPMVMRSDTNTHTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEE 374
                     |:.....:|.|:.:   ....|.:...|..||..:.|||:|.||||||.:.||:.:
Mouse   556 ---------KRPHMDPRPAVVPA---LAALSTRKPPRLQDFRCLAVLGRGHFGKVLLVQYKGTGK 608

  Fly   375 LYAIKILKKDVIIQDDDVECTMIEKRVL-ALGEK-PPFLVQLHSCFQTMDRLFFVMEYVNGGDLM 437
            .||||.|||..::..|:::....|||:| .:|.. .|||:.|.:|.||.....||.|::.|||||
Mouse   609 YYAIKALKKQEVLGRDEIDSLYCEKRILETVGRTGHPFLLSLLACLQTSSHACFVTEFLPGGDLM 673

  Fly   438 FQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENI-V 501
            .||.: ..|.||.|.||.|.:..||.|||.|.|:||||||||:||||.|.:||||||:|||.| .
Mouse   674 AQIHE-DVFPEPQACFYLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGF 737

  Fly   502 GDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNV 566
            ||:|: ||||||:::|||::..:.|.::||||..||||||||||:.||.|:.|||:|..|...:|
Mouse   738 GDRTS-TFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFECIVSADV 801

  Fly   567 SYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKH 631
            ..|..||.:..|..:..|.|.|.||||.|....|::::.||||..:|:.:..|.|||||.|.:..
Mouse   802 PCPHFLSVQGLELIQKLLQKSPEKRLGAGERDAEEIKVQPFFRTTNWQALLARTVQPPFVPTLCG 866

  Fly   632 RKDVSNFDKQFTSEKTDLT-PTDKVFMMNLDQSEFVGFSYMNPEYVFS 678
            ..|:..|:.:|||....|| |..:..:....|:.|..|.:::.:::.|
Mouse   867 PADLRYFEGEFTSLPPTLTPPVSQSSLTARQQAAFRDFDFVSEQFLES 914

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pkc53ENP_725626.1 C1_cPKC_rpt1 44..110 CDD:410383
C1_cPKC_rpt2 120..173 CDD:410386 11/46 (24%)
C2_PKC_alpha_gamma 177..307 CDD:175992 21/140 (15%)
STKc_cPKC 353..672 CDD:270739 151/322 (47%)
Pkn3XP_030107417.1 HR1_PKN_1 23..88 CDD:212012
HR1 103..176 CDD:469609
HR1 203..>257 CDD:469609
C2 357..444 CDD:472691 6/23 (26%)
STKc_PKN 584..909 CDD:270741 152/326 (47%)
Blue background indicates that the domain is not in the aligned region.

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