DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc53E and Prkcz

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	XP_038965237.1	Gene:	Prkcz / 25522	RGDID:	3399	Length:	605	Species:	Rattus norvegicus

Alignment Length:	661	Identity:	229/661 - (34%)
Similarity:	317/661 - (47%)	Gaps:	151/661 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 CSHCKDFICGYQSGY----AWMGFGKQGFQCQVCS------------------YVVH--KRCHEY 99
            |...:| :||....:    .|:  ..:|..|.|.|                  .::|  ....|.
  Rat    41 CEEVRD-MCGLHQQHPLTLKWV--DSEGDPCTVSSQMELEEAFRLACQGRDEVLIIHVFPSIPEQ 102

  Fly   100 VTFICPGKDKGIDSDSPK--------TQHNFEPFTYAGPTFCDHCGSLLYGIYHQGLKCSACDMN 156
            ....|||:||.|.....:        ..|.|:...:....:|..|...::|:..||.:|..|.:.
  Rat   103 PGMPCPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLL 167

  Fly   157 VHARCKENVPSLCGCDHTERRGRIYLEINVKENLLTVQIKEGRNLIPMDPNGLSDPYVKVKLIPD 221
            ||.||...||..|                            .|::..:.|:  .:|.|      |
  Rat   168 VHKRCHVLVPLTC----------------------------RRHMDSVMPS--QEPPV------D 196

  Fly   222 DKDQSKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRTSRNDFMGALSFGISEIIK 286
            ||:..                    .||..|:.|...|...|           .|.:..::.|..
  Rat   197 DKNDG--------------------VDLPSEETDGIALHSTW-----------CATARPVAYISS 230

  Fly   287 NPTNGWFKLLTQDEGEYYNVPCADDEQDLLKLKQKPSQKKPMVMRSDTNTHTSSKKDMIRAT--- 348
            :..:...|               ||.:||          ||::          ...|.|:.:
  Rat   231 SRKHDNIK---------------DDSEDL----------KPVI----------DGVDGIKISQGL 260

  Fly   349 ---DFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPF 410
               ||:.|:|:|:||:.||||...|.::::||:|::||:::..|:|::....||.|.......||
  Rat   261 GLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPF 325

  Fly   411 LVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDL 475
            ||.|||||||..|||.|:||||||||||.:|:..|..|..|.||||||...|.|||.:||:||||
  Rat   326 LVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDL 390

  Fly   476 KLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLY 540
            ||||||||||||:|:.|:|||||.:....||.||||||:||||||:..:.||.||||||.|||::
  Rat   391 KLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMF 455

  Fly   541 EMLVGQPPF-------DGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGC-GSS 597
            ||:.|:.||       |...|:.||..|.:..:..|:.||.:|....||||.|.|.:|||| ..:
  Rat   456 EMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQT 520

  Fly   598 GEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDKVFMMNLDQ 662
            |..|::.|.|||.|||:.:|.::..|||:|:|.....:.|||.|||||...|||.|:..:..:||
  Rat   521 GFSDIKSHAFFRSIDWDLLEKKQTLPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDVIKRIDQ 585

  Fly   663 SEFVGFSYMNP 673
            |||.||.|:||
  Rat   586 SEFEGFEYINP 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	15/74 (20%)
		C1_cPKC_rpt2	120..173	CDD:410386	16/52 (31%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	16/129 (12%)
		STKc_cPKC	353..672	CDD:270739	168/326 (52%)
Prkcz	XP_038965237.1	PB1_aPKC	16..98	CDD:99725	10/59 (17%)
		C1_aPKC_zeta	129..183	CDD:410448	16/81 (20%)
		STKc_aPKC_zeta	249..605	CDD:270768	174/348 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343093
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850