Protein Alignment Pkc53E and pck2

DIOPT Version :10

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_595950.1
• Gene: pck2 / 2539649
• PomBaseID: SPBC12D12.04C
• Length: 1016
• Species: Schizosaccharomyces pombe
• Alignment Length: 668
• Identity: 253/668 - (37%)
• Similarity: 353/668 - (52%)
• Gaps: 81/668 - (12%)

  Fly    31 RKGAL--KKKNVFNVKDHCFIARFFKQPTFCSHCKDFICGYQSGYAWMGFGKQGFQCQVCSYVVH 93
            |:||:  :|::|..|..|.|:...|.|...|:.|.:|:           ....|.||..|.|..|
pombe   389 RQGAIRQRKESVHEVYGHKFLQHQFYQIMRCALCGEFL-----------KNAAGMQCIDCHYTCH 442

  Fly    94 KRCHEYVTFICPGKDKGIDSDSPKTQ---------HNFEPFTYAGPTFCDHCGSLLYGIYHQGLK 149
            |:|:..|...|..|    .|||..::         |:||..|..|..:|.|||.:|........|
pombe   443 KKCYPKVVTKCISK----SSDSASSEYEKINHRIPHHFESHTNIGANWCCHCGYILPLGRKTARK 503

  Fly   150 CSACDMNVHARCKENVPSLCGCDHTERRGRIYLEINVKENLLTVQIKEGRNLIPMDPNGLSDPYV 214
            |:.|.:..||:|...||..||.. .|...|:..||...:.....|.|:            ...:.
pombe   504 CTECGITAHAQCVHLVPDFCGMS-MEMANRVISEIRTTKIYKAQQHKQ------------KSSHH 555

  Fly   215 KVKLIPDDKDQSKKKTRTIKACLNPVWNETLTYDLKPED----KDRRILIEVWDWDRTSRNDFMG 275
            |.......|..|.|.....||.::  ...|.|..:.|.|    ..:.:.||      ..:...:.
pombe   556 KHHHHKKSKSSSSKHKENDKASVS--ITTTTTPSITPADPVPTSPKPLAIE------PVKRKPVH 612

  Fly   276 ALSFGISEIIKNPTNGWFKLLTQDEGEYYNVPCADDEQDLLKLKQKP----SQKKPMVMRS-DTN 335
            |.:..::.:..|......:::.|.         .||:.|.|   .||    :.|:|:.:.| :|:
pombe   613 AGNLEVTSVSDNKLGATVQVVEQK---------VDDKADAL---TKPPSLDAVKEPIPVPSVETS 665

  Fly   336 ------THTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVEC 394
                  ||   |...|...||.|:.|||||:||||:|||.|..::|||||:|||:.|:::|:||.
pombe   666 VVAQDLTH---KAKRIGLEDFTFLSVLGKGNFGKVMLAELKSEKQLYAIKVLKKEFILENDEVES 727

  Fly   395 TMIEKRV--LALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAE 457
            |..||||  :|..|:.||||.|||||||..|::|||::|:|||||..||| .:|....|.|||||
pombe   728 TKSEKRVFLVANRERHPFLVNLHSCFQTETRIYFVMDFVSGGDLMLHIQQ-EQFSRRRAQFYAAE 791

  Fly   458 IAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIIL 522
            :...|.:.|..||:||||||||:||..|||||:||:|:|||::..|.||.||||||:::||||:|
pombe   792 VCLALKYFHDNGIIYRDLKLDNILLSPDGHVKVADYGLCKEDMWHDNTTATFCGTPEFMAPEILL 856

  Fly   523 YQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQ 587
            .|.|.:||||||:|||:|:||:||.||.||||||:|.||......||..:.:::....:..||:.
pombe   857 EQQYTRSVDWWAFGVLIYQMLLGQSPFRGEDEEEIFDAILSDEPLYPIHMPRDSVSILQQLLTRD 921

  Fly   588 PNKRLGCGSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPT 652
            |.||||.|.:..|||..||||..|:|:.|.::..|||:.|.:....|...||::||.|...|||.
pombe   922 PKKRLGSGPNDAEDVMTHPFFSNINWDDIYHKRTQPPYIPSLNSPTDTKYFDEEFTRELPVLTPV 986

  Fly   653 DKVFMMNLDQSEFVGFSY 670
            :.:....: |..|.||||
pombe   987 NSILTKEM-QQHFEGFSY 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	18/65 (28%)
		C1_cPKC_rpt2	120..173	CDD:410386	20/52 (38%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	20/133 (15%)
		STKc_cPKC	353..672	CDD:270739	168/320 (53%)
pck2	NP_595950.1	HR1_PKC-like_1_fungi	2..73	CDD:212011
		HR1_PKC-like_2_fungi	115..186	CDD:212010
		C2_fungal_Pkc1p	213..320	CDD:176071
		C1_ScPKC1-like_rpt1	404..454	CDD:410372	16/60 (27%)
		C1_ScPKC1-like_rpt2	470..528	CDD:410373	20/58 (34%)
		STKc_PKC	688..1003	CDD:270722	166/316 (53%)