DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc53E and Akt2

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	XP_008757330.1	Gene:	Akt2 / 25233	RGDID:	2082	Length:	496	Species:	Rattus norvegicus

Alignment Length:	389	Identity:	161/389 - (41%)
Similarity:	237/389 - (60%)	Gaps:	23/389 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 YNVPCADDEQDLLK--------LKQKPSQKKPMVMR----SDTNTH------TSSKKDMIRATDF 350
            ::|...|:.::.::        |||:...:..|..:    ||::|.      .|..:..:...||
  Rat   103 FHVDSPDEREEWIRAIQMVANSLKQRGPGEDAMDYKCGSPSDSSTSEMMEVAVSKARAKVTMNDF 167

  Fly   351 NFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLH 415
            :::|:||||:||||:|...|.:...||:|||:|:|||..|:|..|:.|.|||. ..:.|||..|.
  Rat   168 DYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ-NTRHPFLTALK 231

  Fly   416 SCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNV 480
            ..|||.|||.|||||.|||:|.|.:.:...|.|..|.||.|||.:.|.:||::.::|||:||:|:
  Rat   232 YAFQTHDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSALEYLHSRDVVYRDIKLENL 296

  Fly   481 LLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVG 545
            :||.|||:||.|||:|||.|....|.|||||||:|:|||::....||::||||..||::|||:.|
  Rat   297 MLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCG 361

  Fly   546 QPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFFRR 610
            :.||..:|.|.||..|....:.:|::|..|||....|.|.|.|.:|||.|.|..::|..|.||..
  Rat   362 RLPFYNQDHERLFELILMEEIRFPRTLGPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLS 426

  Fly   611 IDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDK---VFMMNLDQ-SEFVGFSY 670
            |:|:.:..:::.|||||::....|...||.:||::...:||.|:   :..:.||| :.|..|||
  Rat   427 INWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGSLELDQRTHFPQFSY 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992	0/2 (0%)
		STKc_cPKC	353..672	CDD:270739	149/322 (46%)
Akt2	XP_008757330.1	PH_PKB	32..126	CDD:269947	2/22 (9%)
		PH	35..121	CDD:278594	2/17 (12%)
		S_TKc	167..424	CDD:214567	126/257 (49%)
		STKc_PKB_beta	171..493	CDD:173686	149/321 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920