Protein Alignment Pkc53E and Prkca

DIOPT Version :10

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: XP_038941139.1
• Gene: Prkca / 24680
• RGDID: 3395
• Length: 722
• Species: Rattus norvegicus
• Alignment Length: 703
• Identity: 451/703 - (64%)
• Similarity: 541/703 - (76%)
• Gaps: 67/703 - (9%)

  Fly    31 RKGALKKKNVFNVKDHCFIARFFKQPTFCSHCKDFICGYQSGYAWMGFGKQGFQCQVCSYVVHKR 95
            |||||::|||..||||.|||||||||||||||.|||        | ||||||||||||.:|||||
  Rat    22 RKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFI--------W-GFGKQGFQCQVCCFVVHKR 77

  Fly    96 CHEYVTFICPGKDKGIDSDSPKTQHNFEPFTYAGPTFCDHCGSLLYGIYHQGLKCSACDMNVHAR 160
            |||:|||.|||.|||.|:|.|:::|.|:..||..|||||||||||||:.|||:||..||||||.:
  Rat    78 CHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQ 142

  Fly   161 CKENVPSLCGCDHTERRGRIYLEINVKENLLTVQIKEGRNLIPMDPNGLSDPYVKVKLIPDDKDQ 225
            |..|||||||.||||:||||||:..|.:..|.|.:::.:||||||||||||||||:|||||.|::
  Rat   143 CVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNE 207

  Fly   226 SKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRTSRNDFMGALSFGISEIIKNPTN 290
            ||:||:||::.|||.|||:.|:.|||.|||||:.:|:||||||:||||||:||||:||::|.|.:
  Rat   208 SKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPAS 272

  Fly   291 GWFKLLTQDEGEYYNVPCAD-DEQDLLKLKQK-------PSQKKPMVMRSDTNTHTSSKKDMIRA 347
            ||:|||.|:||||||||..: ||:..::|:||       |:..| ::..|:.....|:..|.::.
  Rat   273 GWYKLLNQEEGEYYNVPIPEGDEEGNVELRQKFEKAKLGPAGNK-VISPSEDRKQPSNNLDRVKL 336

  Fly   348 TDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLV 412
            |||||:.||||||||||:||:|||:|||||||||||||:||||||||||:|||||||.:|||||.
  Rat   337 TDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLT 401

  Fly   413 QLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKL 477
            ||||||||:|||:||||||||||||:.|||.||||||.||||||||:.||||||.:||:||||||
  Rat   402 QLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKL 466

  Fly   478 DNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEM 542
            |||:||::||:||||||||||:::...||:||||||||||||||.||||||||||||||||||||
  Rat   467 DNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEM 531

  Fly   543 LVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPF 607
            |.||||||||||:|||.:|.:|||||||||||||...|||.:||.|.||||||..||.|||.|.|
  Rat   532 LAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAF 596

  Fly   608 FRRIDWEKIENREVQPPFKPKIKHRKDV------------------------------------- 635
            ||||||||:||||:|||||||::...:|
  Rat   597 FRRIDWEKLENREIQPPFKPKVQCTAEVRGFTAFSTQLFLILDISNSSPLSVLILQNFCTKMHWL 661

  Fly   636 ------------SNFDKQFTSEKTDLTPTDKVFMMNLDQSEFVGFSYMNPEYV 676
                        .||||.||..:..|||.|::.:.|:|||:|.||||:||::|
  Rat   662 QWASRPSCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFV 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	49/65 (75%)
		C1_cPKC_rpt2	120..173	CDD:410386	36/52 (69%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	85/129 (66%)
		STKc_cPKC	353..672	CDD:270739	243/367 (66%)
Prkca	XP_038941139.1	C1_cPKC_rpt1	35..92	CDD:410383	49/65 (75%)
		C1_cPKC_rpt2	102..155	CDD:410386	36/52 (69%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	85/129 (66%)
		Protein Kinases, catalytic domain	328..718	CDD:473864	253/387 (65%)