back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkc53E and AKT2

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_001617.1	Gene:	AKT2 / 208	HGNCID:	392	Length:	481	Species:	Homo sapiens

Alignment Length:	389	Identity:	161/389 - (41%)
Similarity:	241/389 - (61%)	Gaps:	23/389 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 YNVPCADDEQDLLK--------LKQKPSQKKPMVMRSDTNTHTSSKKDM----------IRATDF 350
            ::|...|:.::.::        |||:...:.||..:..:.:.:|:.::|          :...||
Human    88 FHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDF 152

  Fly   351 NFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLH 415
            :::|:||||:||||:|...|.:...||:|||:|:|||..|:|..|:.|.|||. ..:.|||..|.
Human   153 DYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ-NTRHPFLTALK 216

  Fly   416 SCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNV 480
            ..|||.|||.|||||.|||:|.|.:.:...|.|..|.||.|||.:.|.:||::.::|||:||:|:
Human   217 YAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENL 281

  Fly   481 LLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVG 545
            :||.|||:||.|||:|||.|....|.|||||||:|:|||::....||::||||..||::|||:.|
Human   282 MLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCG 346

  Fly   546 QPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFFRR 610
            :.||..:|.|.||..|....:.:|::||.|||....|.|.|.|.:|||.|.|..::|..|.||..
Human   347 RLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLS 411

  Fly   611 IDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDK---VFMMNLDQ-SEFVGFSY 670
            |:|:.:..:::.|||||::....|...||.:||::...:||.|:   :.::.||| :.|..|||
Human   412 INWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSY 475

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.