DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkc53E and Prkcq

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_032885.1	Gene:	Prkcq / 18761	MGIID:	97601	Length:	707	Species:	Mus musculus

Alignment Length:	672	Identity:	281/672 - (41%)
Similarity:	369/672 - (54%)	Gaps:	146/672 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 RKGALKKKNVFNVKDHCFIARFFKQPTFCSHCKDFICGYQSGYAWMGFGKQGFQCQVCSYVVHKR 95
            |:||:|:..|.:||.|.|.|.||.||||||.|.:|:        | |..|||:||:.|:..:||:
Mouse   145 RRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV--------W-GLNKQGYQCRQCNAAIHKK 200

  Fly    96 CHEYVTFICPGKDKGIDS------------DSPKTQHNFEPFTYAGPTFCDHCGSLLYGIYHQGL 148
            |.:.|...|.|  ..|:|            |.|   |.|:.:.|..||||:|||:||:|:..|||
Mouse   201 CIDKVIAKCTG--SAINSRETMFHKERFKIDMP---HRFKVYNYKSPTFCEHCGTLLWGLARQGL 260

  Fly   149 KCSACDMNVHARCKENVPSLCGCDHTERRGRIYLEINVKENLLTVQIKEGRNLIPMDPNGLSDPY 213
            ||.||.||||.||:..|.:|||             ||.|      .:.|...:|
Mouse   261 KCDACGMNVHHRCQTKVANLCG-------------INQK------LMAEALAMI----------- 295

  Fly   214 VKVKLIPDDKDQSKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRTSRNDFM-GAL 277
                       :|.::.|::                                 |.|.:.|. |.:
Mouse   296 -----------ESTQQARSL---------------------------------RDSEHIFREGPV 316

  Fly   278 SFGISEIIKNPTNGWFKLLTQDEGEYYNVPCADDEQDLLKLKQKPSQKKPMVMRSDTNTHTSSKK 342
            ..|:....||.|               ..||.          ..|.:::|..:..|:....|:|.
Mouse   317 EIGLPCSTKNET---------------RPPCV----------PTPGKREPQGISWDSPLDGSNKS 356

  Fly   343 D----------------MIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDD 391
            .                .::..||...|:|||||||||.|||.|.:.:.:|||.|||||::.|||
Mouse   357 AGPPEPEVSMRRTSLQLKLKIDDFILHKMLGKGSFGKVFLAEFKRTNQFFAIKALKKDVVLMDDD 421

  Fly   392 VECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAA 456
            |||||:|||||:|..:.|||..:...|||.:.|||||||:||||||:.||...||....|.||||
Mouse   422 VECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAA 486

  Fly   457 EIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEII 521
            |:..||.|||:|||:||||||||:|||.|||:|||||||||||::||..|.|||||||||||||:
Mouse   487 EVILGLQFLHSKGIVYRDLKLDNILLDRDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEIL 551

  Fly   522 LYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTK 586
            |.|.|..|||||::|||:||||:||.||.|:||||||.:|...|..||:.|.:|||:.......:
Mouse   552 LGQKYNHSVDWWSFGVLVYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEREAKDLLVKLFVR 616

  Fly   587 QPNKRLGCGSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTP 651
            :|.||||.    ..|:|.||.||.|:||::|.:|:.|||:||:|...|.|||||:|.|||..|:.
Mouse   617 EPEKRLGV----RGDIRQHPLFREINWEELERKEIDPPFRPKVKSPYDCSNFDKEFLSEKPRLSF 677

  Fly   652 TDKVFMMNLDQSEFVGFSYMNP 673
            .|:..:.::||:.|..||::||
Mouse   678 ADRALINSMDQNMFSNFSFINP 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	28/65 (43%)
		C1_cPKC_rpt2	120..173	CDD:410386	30/52 (58%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	15/130 (12%)
		STKc_cPKC	353..672	CDD:270739	187/318 (59%)
Prkcq	NP_032885.1	C1_1	160..212	CDD:278556	27/62 (44%)
		C1_1	232..284	CDD:278556	30/64 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..365		8/62 (13%)
		STKc_nPKC_theta	374..704	CDD:270770	191/330 (58%)
		S_TKc	380..634	CDD:214567	158/257 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940