DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkc53E and Prkce

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_035234.1	Gene:	Prkce / 18754	MGIID:	97599	Length:	737	Species:	Mus musculus

Alignment Length:	690	Identity:	310/690 - (44%)
Similarity:	408/690 - (59%)	Gaps:	118/690 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GAEGEAVGEN-------KMKSRLRKGALKKKNVFNVKDHCFIARFFKQPTFCSHCKDFICGYQSG 72
            |:.|||..:|       :|:.|.|:||:::: |..|..|.|:|.:.:|||:||||:|||
Mouse   133 GSSGEAPKDNEERVFRERMRPRKRQGAVRRR-VHQVNGHKFMATYLRQPTYCSHCRDFI------ 190

  Fly    73 YAWMGFGKQGFQCQVCSYVVHKRCHEYVTFICPGKDKGIDSDSPKTQ-------HNFEPFTYAGP 130
              |...||||:|||||:.||||||||.:...|.|..|....|...:|       |.|....|..|
Mouse   191 --WGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDEVGSQRFSVNMPHKFGIHNYKVP 253

  Fly   131 TFCDHCGSLLYGIYHQGLKCSACDMNVHARCKENVPSLCGCDHTERRG--RIYLEINVKENLLTV 193
            ||||||||||:|:..|||:|..|.||||.||:.||...||.|   .||  ::..::.|..:.:|.
Mouse   254 TFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVD---ARGIAKVLADLGVTPDKITN 315

  Fly   194 QIKEGRNLI-----PMDPNGLSDPYVKVKLIPDDKDQSKKKTRTIKACLNPVWNETLTYDLKPED 253
            ..:..:.|.     |...:|.|         |.:.|:||....:                  |.|
Mouse   316 SGQRRKKLAAGAESPQPASGNS---------PSEDDRSKSAPTS------------------PCD 353

  Fly   254 KDRRILIEVWDWDRTSRNDFMGALSFGISEIIKNPTNGWFKLLTQDEGEYYNVPCADDEQDLLKL 318
            ::.:.|          .|:...||||                  .:.||.:....|.|.|    |
Mouse   354 QELKEL----------ENNIRKALSF------------------DNRGEEHRASSATDGQ----L 386

  Fly   319 -------KQKPSQKKPMVMRSDTNTHTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELY 376
                   :.:|.|.|.:.:                 .:|||||||||||||||:|||.||.:|:|
Mouse   387 ASPGENGEVRPGQAKRLGL-----------------DEFNFIKVLGKGSFGKVMLAELKGKDEVY 434

  Fly   377 AIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQ 441
            |:|:||||||:|||||:|||.|||:|||..|.|:|.||:.||||.||||||||||||||||||||
Mouse   435 AVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQ 499

  Fly   442 QFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTT 506
            :..||.||.:.|||||:.:.|.|||..|::||||||||:||||:||.|:||||||||.|:...||
Mouse   500 RSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGIMNGVTT 564

  Fly   507 KTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKS 571
            .|||||||||||||:....||.||||||.|||:|||:.|||||:.::|::||.:|...:|.||..
Mouse   565 TTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVW 629

  Fly   572 LSKEAKEACKGFLTKQPNKRLGC--GSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKD 634
            |||||....|.|:||.|:|||||  ..:||:.::.||||:.|||..:|.::::|||||:||.::|
Mouse   630 LSKEAVSILKAFMTKNPHKRLGCVAAQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRD 694

  Fly   635 VSNFDKQFTSEKTDLTPTDKVFMMNLDQSEFVGFSYMNPE 674
            |:|||:.||.|:..||..|:..:..::|.||.||||...:
Mouse   695 VNNFDQDFTREEPILTLVDEAIIKQINQEEFKGFSYFGED 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	33/65 (51%)
		C1_cPKC_rpt2	120..173	CDD:410386	30/52 (58%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	22/136 (16%)
		STKc_cPKC	353..672	CDD:270739	199/320 (62%)
Prkce	NP_035234.1	C2_PKC_epsilon	3..135	CDD:175981	1/1 (100%)
		C1_1	170..220	CDD:278556	31/57 (54%)
		Interaction with actin	223..228		1/4 (25%)
		C1_1	243..295	CDD:278556	30/51 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	310..356		11/72 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..398		6/31 (19%)
		S_TKc	408..668	CDD:214567	171/259 (66%)
		STKc_nPKC_epsilon	412..732	CDD:270743	198/319 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839298
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51944
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.880