DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkc53E and Prkcg

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_035232.1	Gene:	Prkcg / 18752	MGIID:	97597	Length:	697	Species:	Mus musculus

Alignment Length:	701	Identity:	427/701 - (60%)
Similarity:	517/701 - (73%)	Gaps:	55/701 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GSDNNGDPQQQGAEGEAVGENKMKSRLRKGALKKKNVFNVKDHCFIARFFKQPTFCSHCKDFICG 68
            |.|:.|.|:....              |||||::|.|..||.|.|.|||||||||||||.|||
Mouse     8 GGDSEGGPRPLFC--------------RKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFI-- 56

  Fly    69 YQSGYAWMGFGKQGFQCQVCSYVVHKRCHEYVTFICPGKDKGIDSDSPKTQHNFEPFTYAGPTFC 133
                  | |.||||.||||||:|||:||||:|||.|||..||..:|.|:.:|.|...:|:.||||
Mouse    57 ------W-GIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFC 114

  Fly   134 DHCGSLLYGIYHQGLKCSACDMNVHARCKENVPSLCGCDHTERRGRIYLEINV-KENLLTVQIKE 197
            |||||||||:.|||:|||.|:||||.||..:||||||.||||||||:.|||.. ..:.:.:.:.|
Mouse   115 DHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTSDEIHITVGE 179

  Fly   198 GRNLIPMDPNGLSDPYVKVKLIPDDKDQSKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILIEV 262
            .|||||||||||||||||:|||||.::.:|:||:|:||.||||||||..::|||.|.:||:.:||
Mouse   180 ARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTKTVKATLNPVWNETFVFNLKPGDVERRLSVEV 244

  Fly   263 WDWDRTSRNDFMGALSFGISEIIKNPTNGWFKLLTQDEGEYYNVPCAD-DEQDLL---------- 316
            ||||||||||||||:|||:||::|.|.:||:|||.|:||||||||.|| |...||
Mouse   245 WDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQKFEACNYPL 309

  Fly   317 ----KLKQKPSQKKPMVMRSDTNTHTSSKK-------DMIRATDFNFIKVLGKGSFGKVLLAERK 370
                :::..||...   :.|.:.:.|.||:       ..:..:||:|:.||||||||||:||||:
Mouse   310 ELYERVRMGPSSSP---IPSPSPSPTDSKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERR 371

  Fly   371 GSEELYAIKILKKDVIIQDDDVECTMIEKRVLAL-----GEKPPFLVQLHSCFQTMDRLFFVMEY 430
            ||:|||||||||||||:|||||:||::|||||||     |.:|.||.||||.|||.|||:|||||
Mouse   372 GSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEY 436

  Fly   431 VNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGM 495
            |.|||||:.|||.||||||.|.|||||||.||||||.:||:|||||||||:|||:||:||.||||
Mouse   437 VTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGM 501

  Fly   496 CKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAA 560
            ||||:....||:||||||||||||||.|||||||||||::||||||||.||||||||||||||.|
Mouse   502 CKENVFPGSTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQA 566

  Fly   561 ITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFFRRIDWEKIENREVQPPF 625
            |.:..|:||||||:||...|||||||.|.||||.|..||..:|.|.|||.||||::|..|:.|||
Mouse   567 IMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIAPPF 631

  Fly   626 KPKIKHRKDVSNFDKQFTSEKTDLTPTDKVFMMNLDQSEFVGFSYMNPEYV 676
            :|:...|.. .||||.||.....|||.|::.:.::||::|.||:|:||::|
Mouse   632 RPRPCGRSG-ENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFV 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	44/65 (68%)
		C1_cPKC_rpt2	120..173	CDD:410386	35/52 (67%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	84/130 (65%)
		STKc_cPKC	353..672	CDD:270739	224/323 (69%)
Prkcg	NP_035232.1	C1_cPKC_rpt1	34..91	CDD:410383	44/65 (68%)
		C1_cPKC_rpt2	101..154	CDD:410386	35/52 (67%)
		C2_PKC_alpha_gamma	158..289	CDD:175992	84/130 (65%)
		STKc_cPKC	354..677	CDD:270739	224/323 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839302
Domainoid	1	1.000	165	1.000	Domainoid score	I3896
eggNOG	1	0.900	-	-		E1_KOG0696
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	954	1.000	Inparanoid score	I337
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51944
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	1	1.000	-	-		otm44268
orthoMCL	1	0.900	-	-		OOG6_103255
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770