Protein Alignment Pkc53E and Prkca

DIOPT Version :10

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: XP_036012317.1
• Gene: Prkca / 18750
• MGIID: 97595
• Length: 688
• Species: Mus musculus
• Alignment Length: 669
• Identity: 451/669 - (67%)
• Similarity: 539/669 - (80%)
• Gaps: 33/669 - (4%)

  Fly    31 RKGALKKKNVFNVKDHCFIARFFKQPTFCSHCKDFICGYQSGYAWMGFGKQGFQCQVCSYVVHKR 95
            |||||::|||..||||.|||||||||||||||.|||        | ||||||||||||.:|||||
Mouse    22 RKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFI--------W-GFGKQGFQCQVCCFVVHKR 77

  Fly    96 CHEYVTFICPGKDKGIDSDSPKTQHNFEPFTYAGPTFCDHCGSLLYGIYHQGLKCSACDMNVHAR 160
            |||:|||.|||.|||.|:|.|:::|.|:..||..|||||||||||||:.|||:||..||||||.:
Mouse    78 CHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQ 142

  Fly   161 CKENVPSLCGCDHTERRGRIYLEINVKENLLTVQIKEGRNLIPMDPNGLSDPYVKVKLIPDDKDQ 225
            |..|||||||.||||:||||||:..|.:..|.|.:::.:||||||||||||||||:|||||.|::
Mouse   143 CVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNE 207

  Fly   226 SKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRTSRNDFMGALSFGISEIIKNPTN 290
            ||:||:||::.|||.|||:.|:.|||.|||||:.:|:||||||:||||||:||||:||::|.|.:
Mouse   208 SKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPAS 272

  Fly   291 GWFKLLTQDEGEYYNVPCAD-DEQDLLKLKQK-------PSQKKPMVMRSDTNTHTSSKKDMIRA 347
            ||:|||.|:||||||||..: ||:..::|:||       |:..| ::..|:.....|:..|.::.
Mouse   273 GWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNK-VISPSEDRKQPSNNLDRVKL 336

  Fly   348 TDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLV 412
            |||||:.||||||||||:||:|||:|||||||||||||:||||||||||:|||||||.:|||||.
Mouse   337 TDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLT 401

  Fly   413 QLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKL 477
            ||||||||:|||:||||||||||||:.|||.||||||.||||||||:.||||||.:||:||||||
Mouse   402 QLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKL 466

  Fly   478 DNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEM 542
            |||:||::||:||||||||||:::...||:||||||||||||||.||||||||||||||||||||
Mouse   467 DNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEM 531

  Fly   543 LVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPF 607
            |.||||||||||:|||.:|.:|||||||||||||...|||.:||.|.||||||..||.|||.|.|
Mouse   532 LAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAF 596

  Fly   608 FRRIDWEKIENREVQPPFKPKIKH---------------RKDVSNFDKQFTSEKTDLTPTDKVFM 657
            ||||||||:||||:|||||||:..               .|...||||.||..:..|||.|::.:
Mouse   597 FRRIDWEKLENREIQPPFKPKVTFCTKMHWLQWASRPSCGKGAENFDKFFTRGQPVLTPPDQLVI 661

  Fly   658 MNLDQSEFVGFSYMNPEYV 676
            .|:|||:|.||||:||::|
Mouse   662 ANIDQSDFEGFSYVNPQFV 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	49/65 (75%)
		C1_cPKC_rpt2	120..173	CDD:410386	36/52 (69%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	85/129 (66%)
		STKc_cPKC	353..672	CDD:270739	243/333 (73%)
Prkca	XP_036012317.1	C1_cPKC_rpt1	35..92	CDD:410383	49/65 (75%)
		C1_cPKC_rpt2	102..155	CDD:410386	36/52 (69%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	85/129 (66%)
		STKc_cPKC_alpha	328..684	CDD:270766	253/353 (72%)