Protein Alignment Pkc53E and Prkaca

DIOPT Version :10

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_032880.1
• Gene: Prkaca / 18747
• MGIID: 97592
• Length: 351
• Species: Mus musculus
• Alignment Length: 346
• Identity: 134/346 - (38%)
• Similarity: 195/346 - (56%)
• Gaps: 23/346 - (6%)

  Fly   309 ADDEQDLLKLKQKPSQKKPMVMRSDTNTHTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSE 373
            |..::|.||..:.|||          ||        .:...|:.||.||.||||:|:|.:.|.|.
Mouse    21 AKAKEDFLKKWETPSQ----------NT--------AQLDQFDRIKTLGTGSFGRVMLVKHKESG 67

  Fly   374 ELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMF 438
            ..||:|||.|..:::...:|.|:.|||:|. ....||||:|...|:....|:.|||||.||::..
Mouse    68 NHYAMKILDKQKVVKLKQIEHTLNEKRILQ-AVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFS 131

  Fly   439 QIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGD 503
            .:::.|:|.||.|.||||:|.....:||:..::|||||.:|:|:|..|::::.|||..| .:.|
Mouse   132 HLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK-RVKG- 194

  Fly   504 KTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSY 568
             .|.|.||||:|:||||||.:.|.|:|||||.|||:|||..|.|||..:...:::..|....|.:
Mouse   195 -RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRF 258

  Fly   569 PKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRK 633
            |...|.:.|:..:..|.....||.|...:|..|::.|.:|...||..|..|:|:.||.||.|...
Mouse   259 PSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPG 323

  Fly   634 DVSNFDKQFTSEKTDLTPTDK 654
            |.|||| .:..|:..::..:|
Mouse   324 DTSNFD-DYEEEEIRVSINEK 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992
		STKc_cPKC	353..672	CDD:270739	124/302 (41%)
Prkaca	NP_032880.1	STKc_PKA	42..331	CDD:271111	123/293 (42%)