DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc53E and pkn-1

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_001360642.1	Gene:	pkn-1 / 181244	WormBaseID:	WBGene00009793	Length:	1137	Species:	Caenorhabditis elegans

Alignment Length:	355	Identity:	163/355 - (45%)
Similarity:	222/355 - (62%)	Gaps:	14/355 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   322 PSQKKPMVMRSDTNTHTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVI 386
            |||..|:......:...||....:....|..|.|||:|.||||:|::...:...||:|:|||..|
Worm   781 PSQAPPVPAVRHIDFFASSDGAPLTVEQFRLISVLGRGHFGKVILSQHNPTSNYYALKVLKKGDI 845

  Fly   387 IQDDDVECTMIEKRVLALGEKP--PFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEP 449
            :..|:||..|:|||:..:..:.  ||||.|:.||||.:.:||.|||..|||||..|.. ..|.|.
Worm   846 LGRDEVESLMVEKRIFEVSSRARHPFLVNLNGCFQTNEHVFFCMEYSMGGDLMRHIHD-DVFDEV 909

  Fly   450 VAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPD 514
            ...||||.:..||.|||...|:|||:||||:|||.:|:|||||||:||||:.....|.||||||:
Worm   910 RGCFYAACVVLGLDFLHKHNIIYRDIKLDNLLLDREGYVKIADFGLCKENMGPFDKTSTFCGTPE 974

  Fly   515 YIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEA 579
            ::|||::....|.:::|||..|||::|||||:|||.|:||||:|.:|...:|.||:.||.|:...
Worm   975 FLAPEVLSDSSYTRAIDWWGLGVLIFEMLVGEPPFSGDDEEEIFDSIISEDVRYPRYLSVESIAI 1039

  Fly   580 CKGFLTKQPNKRLGCGSSGEEDVRLHPFFRRIDWE--KIENREVQPPFKPKIKHRKDVSNFDKQF 642
            .:..|.|.|.||||.|....||:::..|||.|.||  |:.|||::|||:|:|::.:||||||.:|
Worm  1040 MRRLLRKVPEKRLGYGERDAEDIKIQRFFRHISWEWDKLLNREIRPPFQPQIRNPEDVSNFDLEF 1104

  Fly   643 TSEKT---------DLTPTDKVFMMNLDQS 663
            |.||.         .:|..|:....|.|.|
Worm  1105 TQEKARFSAASSTRPITEADQRLFNNFDFS 1134

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992
		STKc_cPKC	353..672	CDD:270739	156/324 (48%)
pkn-1	NP_001360642.1	HR1_PKN_1	188..253	CDD:212012
		HR1_PKN_2	273..339	CDD:212013
		HR1	344..410	CDD:381797
		C2	527..>589	CDD:387358
		STKc_PKN	809..1134	CDD:270741	156/325 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940