Protein Alignment Pkc53E and pkc-2

DIOPT Version :10

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_001359883.1
• Gene: pkc-2 / 181166
• WormBaseID: WBGene00004033
• Length: 753
• Species: Caenorhabditis elegans
• Alignment Length: 680
• Identity: 442/680 - (65%)
• Similarity: 531/680 - (78%)
• Gaps: 34/680 - (5%)

  Fly    14 QGAEGEAVGENKMKSRLRKGALKKKNVFNVKDHCFIARFFKQPTFCSHCKDFICGYQSGYAWMGF 78
            |..||:|.        :|:|||::|||..:|.|.||||||||||||||||||:        | |.
 Worm    86 QRIEGKAF--------VRRGALRQKNVHEIKSHKFIARFFKQPTFCSHCKDFL--------W-GI 133

  Fly    79 GKQGFQCQVCSYVVHKRCHEYVTFICPGKDKGIDSDSPKTQHNFEPFTYAGPTFCDHCGSLLYGI 143
            .|||||||||:.||||||||:|.|.|||.|||:|:|.|:.||.::..||:.||||||||||||||
 Worm   134 TKQGFQCQVCTLVVHKRCHEFVNFACPGADKGVDTDDPRQQHKWKVQTYSSPTFCDHCGSLLYGI 198

  Fly   144 YHQGLKCSACDMNVHARCKENVPSLCGCDHTERRGRIYLEINVKENLLTVQIKEGRNLIPMDPNG 208
            .|||:||.:||.|||.||.:|||::||.|:||:|||:.:|.:::.:.||::|.|.:|||||||||
 Worm   199 LHQGMKCQSCDTNVHHRCVKNVPNMCGTDNTEKRGRLRIEAHIENDQLTIKILEAKNLIPMDPNG 263

  Fly   209 LSDPYVKVKLIPDDKD-QSKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRTSRND 272
            |||||||.||||:|.. :||:||:|::|.|||.||||.||.|.|.|||||:.|||||||||||||
 Worm   264 LSDPYVKCKLIPEDSGCKSKQKTKTLRATLNPQWNETFTYKLLPGDKDRRLSIEVWDWDRTSRND 328

  Fly   273 FMGALSFGISEIIKNPTNGWFKLLTQDEGEYYNVPCADD-EQDLLKLKQKPSQ------------ 324
            |||:|||||||::|...:||:|||:.:|||:||:....: ::|:.|:::|.::
 Worm   329 FMGSLSFGISELMKEAASGWYKLLSAEEGEFYNINITPEYDEDMEKVRKKMNENFITRDNSSSKP 393

  Fly   325 KKPMVMRSDTNTHTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQD 389
            |.|...|:.|....||..::|:|:||||:.||||||||||||.|:|.::||:|||:|||||||||
 Worm   394 KDPAAPRASTLPLGSSNHNVIKASDFNFLTVLGKGSFGKVLLGEQKTTKELFAIKVLKKDVIIQD 458

  Fly   390 DDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFY 454
            |||||||.|||||||.|||.|||.|||||||||||:||||:|||||||:||||.|||||||||||
 Worm   459 DDVECTMTEKRVLALPEKPSFLVALHSCFQTMDRLYFVMEFVNGGDLMYQIQQVGKFKEPVAVFY 523

  Fly   455 AAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPE 519
            |||||.||||||:|||:|||||||||:|:.|||:||.|||||||||.||.|||||||||||||||
 Worm   524 AAEIAVGLFFLHSKGIIYRDLKLDNVMLERDGHIKITDFGMCKENIFGDATTKTFCGTPDYIAPE 588

  Fly   520 IILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFL 584
            ||||||||||||||||||||:|||.||||||||||:|||.|||:|||||||||||||...||..|
 Worm   589 IILYQPYGKSVDWWAYGVLLFEMLAGQPPFDGEDEDELFTAITEHNVSYPKSLSKEAVSLCKALL 653

  Fly   585 TKQPNKRLGC---GSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEK 646
            .|.|:|||||   ..|...|::.|||||||||.|||.|::|||||||:|..:...|||..|....
 Worm   654 IKNPSKRLGCTGDDESASRDIKEHPFFRRIDWFKIETRQIQPPFKPKLKTDRSTENFDHSFLKLP 718

  Fly   647 TDLTPTDKVFMMNLDQSEFVGFSYMNPEYV 676
            |.:||.|...:.||...||..||::||.||
 Worm   719 TKMTPPDWEVLENLKGDEFSNFSFVNPFYV 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	45/65 (69%)
		C1_cPKC_rpt2	120..173	CDD:410386	34/52 (65%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	85/130 (65%)
		STKc_cPKC	353..672	CDD:270739	239/321 (74%)
pkc-2	NP_001359883.1	C1_cPKC_rpt1	108..165	CDD:410383	45/65 (69%)
		C1_cPKC_rpt2	175..228	CDD:410386	34/52 (65%)
		C2_PKC_alpha_gamma	232..362	CDD:175992	84/129 (65%)
		STKc_cPKC	422..744	CDD:270739	239/321 (74%)