DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pkc53E and sax-1

DIOPT Version :10

Sequence 1:NP_725626.1 Gene:Pkc53E / 48311 FlyBaseID:FBgn0003091 Length:679 Species:Drosophila melanogaster
Sequence 2:NP_508627.5 Gene:sax-1 / 180655 WormBaseID:WBGene00004727 Length:476 Species:Caenorhabditis elegans


Alignment Length:425 Identity:138/425 - (32%)
Similarity:216/425 - (50%) Gaps:67/425 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   303 YYN---VPCADDEQDLLKLKQ---------KPSQKKPMVMRSDTNTHTSSKKDMIRATDFNFIKV 355
            ||:   ..||:.|..|.||::         :..::|..:..|....:...|:..:...||..:||
 Worm    28 YYSKRVTQCAERENRLKKLEEDISARGLSDEEKEEKRKIHHSKETDYLRLKRTRLTVNDFESLKV 92

  Fly   356 LGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQT 420
            :|:|:||:|.|.::..:..:||:|||:|..:::.:.......|:.:|:..: ..::|:::..||.
 Worm    93 IGRGAFGEVRLVQKHDTGHIYAMKILRKSEMVEKEQTAHVRAERDILSEAD-CDWVVKMYYSFQD 156

  Fly   421 MDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDAD 485
            ...|:.|||::.|||:|..:.:.....|....||.||.|..:.|:|:.|.::||:|.||:||||.
 Worm   157 YSNLYLVMEFLPGGDMMTLLIKKDTLTEEATQFYIAEAALAIQFIHSLGFIHRDIKPDNLLLDAR 221

  Fly   486 GHVKIADFGMC---------------KENIVGDKTTKTF--------------------CGTPDY 515
            ||||::|||:|               ...:..|..:|.|                    .|||||
 Worm   222 GHVKLSDFGLCTGLKKFHRTDHYRNWPSTLPPDFISKPFESKRKAETWKRNRRAYAYSTVGTPDY 286

  Fly   516 IAPEIILYQP--YGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITD--HNVSYPKS--LSK 574
            ||||:  :||  |.||.|||:.||::||||:|.|||..|..:|.:..:.:  ..:.:|..  :|.
 Worm   287 IAPEV--FQPNGYTKSCDWWSLGVIMYEMLIGYPPFCSELPQETYRKVINWQQTLVFPSDVPISI 349

  Fly   575 EAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFD 639
            |||...|.|.. :..:||| ...|.::::..||.:||||..|  ||..||.:..:|...|.||||
 Worm   350 EAKATIKRFCC-EAERRLG-NHGGLDEIKQCPFVKRIDWNHI--RERPPPIRVTVKSIDDTSNFD 410

  Fly   640 KQFTSEKTDLT-PTDKVFMMNLD---QSEFVGFSY 670
             .|..|  ||| ||..:......   :.|||.|:|
 Worm   411 -DFPDE--DLTWPTSTLIRPEEQPGRRGEFVDFTY 442

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pkc53ENP_725626.1 C1_cPKC_rpt1 44..110 CDD:410383
C1_cPKC_rpt2 120..173 CDD:410386
C2_PKC_alpha_gamma 177..307 CDD:175992 2/6 (33%)
STKc_cPKC 353..672 CDD:270739 125/363 (34%)
sax-1NP_508627.5 MobB_NDR-like 18..82 CDD:439270 11/53 (21%)
STKc_NDR_like 85..443 CDD:270750 127/368 (35%)
Blue background indicates that the domain is not in the aligned region.

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