Protein Alignment Pkc53E and tpa-1

DIOPT Version :10

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_001379590.1
• Gene: tpa-1 / 176825
• WormBaseID: WBGene00006599
• Length: 704
• Species: Caenorhabditis elegans
• Alignment Length: 675
• Identity: 278/675 - (41%)
• Similarity: 362/675 - (53%)
• Gaps: 129/675 - (19%)

  Fly    23 ENKMKSR--------LRKGALKKKNVFNVKDHCFIARFFKQPTFCSHCKDFICGYQSGYAWMGFG 79
            |:.|.||        .|:||:|...|..::.|.|:|.||:||.|||.|.||:        | |..
 Worm   135 EDIMTSRSNSGPGIQRRRGAIKHARVHEIRGHQFVATFFRQPHFCSLCSDFM--------W-GLN 190

  Fly    80 KQGFQCQVCSYVVHKRCHEYVTFICPGKDKGIDS----------DSPKTQHNFEPFTYAGPTFCD 134
            |||:|||:||..|||:|||.|...|||..|....          |.|   |.|:.:.:..|||||
 Worm   191 KQGYQCQLCSAAVHKKCHEKVIMQCPGSAKNTKETMALKERFKVDIP---HRFKTYNFKSPTFCD 252

  Fly   135 HCGSLLYGIYHQGLKCSACDMNVHARCKENVPSLCGCDHTERRGRIYLEINVKENLLTVQIKEGR 199
            ||||:|||::.|||:|..|::..|.:|:..:.:|||             :|.|:
 Worm   253 HCGSMLYGLFKQGLRCEVCNVACHHKCERLMSNLCG-------------VNQKQ----------- 293

  Fly   200 NLIPMDPNGLSDPYVKVKLIPDDKDQSKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILIEVWD 264
                     ||:.|.::          |:.|....:|...:.|..|.
 Worm   294 ---------LSEMYHEI----------KRGTHATASCPPNIANLHLN------------------ 321

  Fly   265 WDRTSRNDFMGALSFGISEIIKNPTNGWFKLLTQDEGEYY--NVPCADDEQDLLKLKQKPSQKKP 327
             ..||:|:  |:|...:..:.|:..   :.:..|.|.:.|  |:....|         .|.:|
 Worm   322 -GETSKNN--GSLPNKLKNLFKSHQ---YSVEEQKETDEYMDNIWGGGD---------GPVKK-- 369

  Fly   328 MVMRSDTNTHTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDV 392
                             .....||.:|||||||||||:|.|.||..|.||:|.||||||::|||.
 Worm   370 -----------------FALPHFNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDT 417

  Fly   393 ECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAE 457
            |||.||:|||.|..:.|||.||...|||.:.|||||||:||||||..|||..||.|....|||.|
 Worm   418 ECTYIERRVLILASQCPFLCQLFCSFQTNEYLFFVMEYLNGGDLMHHIQQIKKFDEARTRFYACE 482

  Fly   458 IAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDK-TTKTFCGTPDYIAPEII 521
            |...|.||||..|:||||||||||||.|||:|:|||||.|..:..:. ...|||||||||:||||
 Worm   483 IVVALQFLHTNNIIYRDLKLDNVLLDCDGHIKLADFGMAKTEMNRENGMASTFCGTPDYISPEII 547

  Fly   522 LYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTK 586
            ..|.|.::||:|::|||:|||||||.||.||.|:|||.:|.:....:||::||||.:.......:
 Worm   548 KGQLYNEAVDFWSFGVLMYEMLVGQSPFHGEGEDELFDSILNERPYFPKTISKEAAKCLSALFDR 612

  Fly   587 QPNKRLGCGSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTP 651
            .||.|||.....:..:|.|.|||.:||::.|||:|.|||||.||...|.||||..||:||..|||
 Worm   613 NPNTRLGMPECPDGPIRQHCFFRGVDWKRFENRQVPPPFKPNIKSNSDASNFDDDFTNEKAALTP 677

  Fly   652 T-DKVFMMNLDQSEFVGFSYMNPEY 675
            . ||..:.::|...|:.|||.||.:
 Worm   678 VHDKNLLASIDPEAFLNFSYTNPHF 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	33/65 (51%)
		C1_cPKC_rpt2	120..173	CDD:410386	24/52 (46%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	20/131 (15%)
		STKc_cPKC	353..672	CDD:270739	182/320 (57%)
tpa-1	NP_001379590.1	C1_nPKC_theta-like_rpt1	159..219	CDD:410384	34/68 (50%)
		C1_nPKC_theta-like_rpt2	238..287	CDD:410387	21/48 (44%)
		STKc_nPKC_theta_like	379..700	CDD:270744	182/320 (57%)