DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc53E and Sgk2

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_604458.1	Gene:	Sgk2 / 171497	RGDID:	620232	Length:	367	Species:	Rattus norvegicus

Alignment Length:	351	Identity:	146/351 - (41%)
Similarity:	219/351 - (62%)	Gaps:	11/351 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 PMVMRSDTNTHTS-SKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDD 390
            |...|::.|.:.. |.....|.|||:|:||:|||::||||||:||.....||:|:|:|..|:::.
  Rat    11 PQPSRANGNINLGPSANPNARPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKNK 75

  Fly   391 DVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYA 455
            :....|.|:.||....:.||||.|...|||.::|:||::|||||:|.|.:|:..:|.||.|.||.
  Rat    76 EQSHIMAERNVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQREHRFLEPRARFYT 140

  Fly   456 AEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEI 520
            ||:|:.:.:||:..|:|||||.:|:|||..|||.:.|||:|||.:..::||.||||||:|:|||:
  Rat   141 AEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKECVEPEETTSTFCGTPEYLAPEV 205

  Fly   521 ILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLT 585
            :..:||.::||||..|.:|||||.|.|||...|..:::..|....:..|...:..|.:..:|.|.
  Rat   206 LRKEPYDRAVDWWCLGAVLYEMLHGLPPFFNTDVAQMYENILHQPLQIPGGRTVAACDLLQGLLH 270

  Fly   586 KQPNKRLGCGSSGEE--DVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTD 648
            |...:|||   |.|:  |::.|.||..|:|:.:.::.:.|||.|.::...|:.:||.:||.|...
  Rat   271 KDQRQRLG---SKEDFLDIKNHMFFSPINWDDLYHKRLTPPFNPNVEGPADLKHFDPEFTQEAVS 332

  Fly   649 ----LTPTDKVFMMNLDQSEFVGFSY 670
                .|| |.:...:...|.|:||||
  Rat   333 KSIGCTP-DTMSSSSGASSAFLGFSY 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992
		STKc_cPKC	353..672	CDD:270739	137/324 (42%)
Sgk2	NP_604458.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		4/16 (25%)
		S_TKc	35..292	CDD:214567	116/259 (45%)
		PKc_like	39..359	CDD:304357	137/323 (42%)
		Nuclear localization signal. /evidence=ECO:0000250	68..77		2/8 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920