Protein Alignment Pkc53E and Sgk3

DIOPT Version :9

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_001032848.1
• Gene: Sgk3 / 170755
• MGIID: 2182368
• Length: 496
• Species: Mus musculus
• Alignment Length: 547
• Identity: 192/547 - (35%)
• Similarity: 277/547 - (50%)
• Gaps: 87/547 - (15%)

  Fly   153 CDMNVHARCKE-NVPSLCGCDHTERRGRIYLEINVKENLLTVQIKEGRNLIPMDPNGLSDPYVKV 216
            |.|:....|.. ::||  ..:|.|::.|    ..|.:.|::|              |.|:.:|..
Mouse     5 CIMDYKESCPSVSIPS--SDEHREKKKR----FTVYKVLVSV--------------GRSEWFVFR 49

  Fly   217 KLIPDDK-DQSKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRTSRNDFMGALSFG 280
            :....|| ..|.||.....|...|.               :||..:.:|      .||:.....|
Mouse    50 RYAEFDKLYNSLKKQFPAMALKIPA---------------KRIFGDNFD------PDFIKQRRAG 93

  Fly   281 ISEIIKN----PTNGWFKLLTQDEGEYYNVPCADDEQDLLKLKQKPSQKKPMV---MRSDTNTHT 338
            ::|.|:|    |             |.||.|   |.:..|::.....|..|..   .||.:..|:
Mouse    94 LNEFIQNLVRYP-------------ELYNHP---DVRAFLQMDSPRHQSDPSEDEDERSTSKPHS 142

  Fly   339 SSKKDMI--------RATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECT 395
            :|:...:        :.|||:|:||:|||||||||||:||...:.||:|:|:|.:::...:.:..
Mouse   143 TSRNINLGPTGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHI 207

  Fly   396 MIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAA 460
            |.|:.||....|.||||.||..|||.::|:||:::||||:|.|.:|:...|.||.|.|||||||:
Mouse   208 MAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEPRARFYAAEIAS 272

  Fly   461 GLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQP 525
            .|.:||:..|:|||||.:|:|||:.|||.:.|||:|||.|....||.||||||:|:|||:|..||
Mouse   273 ALGYLHSIKIVYRDLKPENILLDSMGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQP 337

  Fly   526 YGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNK 590
            |..:||||..|.:|||||.|.|||...|..|::..|....::....:|..|....:..|.|....
Mouse   338 YDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLNLRPGVSLTAWSILEELLEKNRQN 402

  Fly   591 RLGCGSSGEED---VRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKT--DLT 650
            |||    .:||   ::.||||..:.|..:..:::.|||.|.:....|:.|||..||.|..  .:.
Mouse   403 RLG----AKEDFLEIQNHPFFESLSWTDLVQKKIPPPFNPNVAGPDDIRNFDAVFTEETVPYSVC 463

  Fly   651 PTDKVFMMNLDQSE----FVGFSYMNP 673
            .:....::|....|    ||||||..|
Mouse   464 VSSDYSIVNASVLEADDAFVGFSYAPP 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386	5/20 (25%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	27/134 (20%)
		STKc_cPKC	353..672	CDD:270739	144/327 (44%)
Sgk3	NP_001032848.1	PX_CISK	12..120	CDD:132780	35/164 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..157		6/35 (17%)
		S_TKc	162..419	CDD:214567	124/260 (48%)
		STKc_SGK3	165..490	CDD:270755	144/328 (44%)
		Nuclear localization signal. /evidence=ECO:0000250	195..205		1/9 (11%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920